Evidence map›Paper›PMID 42646623›Full record

ReviewMedical sciences (Basel, Switzerland)2026

Selective Neuronal Vulnerability to Alpha-Synuclein Pathology in Parkinson's Disease: A Critical Review of Mechanistic Rationale and Biomarker Stratification.

Livia Livinț-Popa, Andreea Nicolaie, Alexandra Mastaleru, Ștefan Socolov, Mihaela Mitrea, Gabriela Popescu, Thomas Gabriel Schreiner, Roxana Covali, Laura-Elena Cucu, Lucia Corina Dima-Cozma and 6 more

Abstract readReview
In one paragraph

Review in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Livia Livinț-PopaDepartment of Neuroscience, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400083 Cluj-Napoca, Romania.
Andreea NicolaieAmerican University of the Caribbean School of Medicine, Miramar, FL 33025, USA.
Alexandra MastaleruGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-0008-9696
Ștefan SocolovGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Mihaela MitreaGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Gabriela PopescuGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0000-7004-6846
Thomas Gabriel SchreinerGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-4495-4004
Roxana CovaliGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-7386-0859
Laura-Elena CucuGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0000-1544-1325
Lucia Corina Dima-CozmaGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Romica Sebastian CozmaGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-3768-6232
Alin CiubotaruGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0003-2079-2383
Raluca OlariuGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0001-1221-5397
Cosmin Mihai CiurumeleaPrevent Institute, 020021 Bucharest, Romania.ORCID 0009-0000-6428-4071
Liana Rada BorzaFaculty of Medicine, Imperial College London, London SW7 2AZ, UK.
Albert VamanuBasic and Clinical Neuroscience Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alpha-SynucleinBiomarkersNeuronsParkinson DiseaseAnimalsHumansMitochondriaalpha-SynucleinBiomarkersalpha-synucleinbiomarkersGBA1glucocerebrosidaselysosomal dysfunctionmitochondrial dysfunctionneurodegenerationneuroinflammationParkinson’s diseaseParkinson’s Vulnerability Indexprecision medicineselective neuronal vulnerability

Identifiers

PMID42646623
PMCPMC13515378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.