ArticleMedical sciences (Basel, Switzerland)2026
Bedside Assessment of PEEP-Induced Volume and Mechanical Power in Mechanically Ventilated Adults Without ARDS: A Post Hoc Analysis.
Article in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesPositive end-expiratory pressure (PEEP) increases end-expiratory lung volume through the addition of PEEP-induced lung volume (PEEPVol), potentially affecting respiratory mechanics and energy load. However, its physiological impact in patients without lung injury remains poorly characterized. We hypothesized that PEEPVol would be closely associated with respiratory system loading beyond conventional respiratory mechanics variables.
methodsWe conducted a secondary analysis of a prospective physiological study including 16 deeply sedated, mechanically ventilated adults without lung disease. A standardized incremental PEEP titration (0-16 cmH
resultsIncremental PEEP significantly increased PEEPVol, plateau pressure, mechanical power, and both static and global strain (all
conclusionsIn patients without lung injury, PEEP-induced increases in lung volume are strongly associated with higher mechanical load and strain, despite minimal changes in compliance or driving pressure. PEEPVol may represent a promising physiological surrogate of static lung deformation and energy transfer, whose potential to improve bedside detection of occult overdistension warrants validation against direct imaging or physiological measurements in larger prospective studies.
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