Evidence map›Paper›PMID 42646517›Full record

ArticleMethods and protocols2026

Suitability of a Fluorescence Method for Flavin Mononucleotide Determination in Modified HTK-Based Perfusion Solutions During Hypothermic Oxygenated Perfusion of Liver Grafts.

Yulia B Basok, Eugenia G Kuznetsova, Aleksandra D Belova, Dmitriy A Morozov, Mikhail A Boldyrev, Artem R Monakhov, Nikita V Grudinin, Vladimir K Bogdanov, Denis M Bondarenko, Stepan I Zubenko and 2 more

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Article in Methods and protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yulia B BasokShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.ORCID 0000-0003-4807-3164
Eugenia G KuznetsovaShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.
Aleksandra D BelovaShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.ORCID 0000-0003-2938-5883
Dmitriy A MorozovShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.
Mikhail A BoldyrevShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.ORCID 0000-0003-4048-3564
Artem R MonakhovShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.ORCID 0000-0002-3537-6601
Nikita V GrudininShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.ORCID 0000-0003-1100-9513
Vladimir K BogdanovShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.
Denis M BondarenkoShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.
Stepan I ZubenkoShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.ORCID 0000-0001-5436-7092
Nidzhat M YusufShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.
Sergey V GautierShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Shchukinskaja St., Moscow 123182, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A comprehensive assessment of allograft quality is essential for predicting successful transplantation and graft survival. Elevated levels of flavin mononucleotide (FMN) in perfusate obtained during hypothermic oxygenated perfusion (HOPE) may serve as a promising predictor of early graft dysfunction and post-transplant complications. The aim of this study was to evaluate the feasibility of applying an FMN determination method to HTK-based perfusion solutions used during liver machine perfusion. The spectrofluorimetric method for FMN determination in modified HTK perfusion solution (modHTK) was evaluated for the following parameters: linearity, accuracy, repeatability, reproducibility, and stability. The study demonstrated the suitability of the quantitative FMN determination method for modHTK solution used during HOPE of liver grafts.

Indexed as

flavin mononucleotideFMNHOPEhypothermic oxygenated machine perfusionliver transplantationperfusion solution

Identifiers

PMID42646517
PMCPMC13515777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.