Evidence map›Paper›PMID 42646461›Full record

ArticleMarine drugs2026

Preparation, Characterization, and pH-Responsive Intestinal Release Properties of Gel Beads Encapsulating Sea Cucumber Mouthpart Peptides.

Yige Wu, Lijun Hu, Yue Li, Tiantian Hao, Zhidong Song, Gongming Wang, Chunna Jiao, Jian Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yige WuCollege of Food Sciences and Technology, Shanghai Ocean University, Shanghai 200120, China.
Lijun HuCollege of Food Sciences and Technology, Shanghai Ocean University, Shanghai 200120, China.
Yue LiCollege of Food Sciences and Technology, Shanghai Ocean University, Shanghai 200120, China.
Tiantian HaoShandong Marine Resource and Environment Research Institute, Yantai 264006, China.
Zhidong SongShandong Marine Resource and Environment Research Institute, Yantai 264006, China.
Gongming WangShandong Marine Resource and Environment Research Institute, Yantai 264006, China.
Chunna JiaoShandong Marine Resource and Environment Research Institute, Yantai 264006, China.
Jian ZhangShandong Marine Resource and Environment Research Institute, Yantai 264006, China.

Funding

National Key Research and Development Program of China No. 2024YFD2402104Shandong Provincial Modern Agricultural Industry Technology System Sea Cucumber Industry Technology System Construction Project SDAIT-22-08
6 · The paper itself

Abstract

Sea cucumber mouthpart peptides (SCPs) are marine bioactive peptides with considerable application potential. However, their oral delivery remains challenging because of their poor stability and low intestinal bioavailability. To develop a delivery system for SCPs with gastric protection and pH-responsive intestinal sustained-release properties, double-layer gel beads (SCP-BMs) were fabricated through ionic gelation, with SCPs as the core material and sodium alginate (SA) and chitosan (CS) as the wall materials. The preparation conditions of the gel beads were optimized using single-factor experiments and response surface methodology (RSM). The optimized gel beads were then characterized for their morphology, thermal stability,

Indexed as

PeptidesSea CucumbersAdministration, OralAlginatesAnimalsAntioxidantsBioactive Peptides, DietaryBiological AvailabilityChitosanDelayed-Action PreparationsDrug CompoundingDrug LiberationGelsGlucuronic AcidHexuronic AcidsHydrogen-Ion ConcentrationAlginatesAntioxidantsBioactive Peptides, DietaryChitosanDelayed-Action PreparationsGelsGlucuronic AcidHexuronic AcidsPeptidesantioxidant activitygel beadssea cucumber mouthpart peptidesstructural characterizationsustained-release performance

Identifiers

PMID42646461
PMCPMC13514753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.