ArticleNanomaterials (Basel, Switzerland)2026
Elemental Boron Nanoparticles for Boron-Neutron Capture Therapy of BT-474 Human Breast Cancer.
Evgenii L Zavjalov, Linga D Romanenko, Olga I Kichakova, Anna I Kasatova, Polina A Kotelnikova, Dmitry S Petrunya, Ekaterina V Barmina, Kuder O Aiyyzhy, Artem A Laktionov, Sergei M Klimentov and 10 more
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In one paragraphArticle in Nanomaterials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
20 authors.
Evgenii L ZavjalovInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Linga D RomanenkoInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Olga I KichakovaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.ORCID 0000-0002-8218-2690 Anna I KasatovaP.N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119333, Russia.ORCID 0000-0002-6641-9344 Polina A KotelnikovaP.N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119333, Russia.ORCID 0000-0001-6570-8147 Dmitry S PetrunyaP.N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119333, Russia.ORCID 0009-0004-9075-5622 Ekaterina V BarminaP.N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119333, Russia.ORCID 0000-0003-0735-2896 Kuder O AiyyzhyProkhorov General Physics Institute, Russian Academy of Sciences, Moscow 119991, Russia.
Artem A LaktionovInstitute of Engineering Physics of Biomedicine, National Research Nuclear University "MEPhI", Moscow 115409, Russia.ORCID 0009-0009-8140-6988 Sergei M KlimentovP.N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119333, Russia.
Anton A PopovInstitute of Engineering Physics of Biomedicine, National Research Nuclear University "MEPhI", Moscow 115409, Russia.ORCID 0000-0001-8902-0371 Maria S GrigoryevaP.N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119333, Russia.ORCID 0000-0003-3759-5186 Timofey A BykovBudker Institute of Nuclear Physics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Vasilisa V PodolyakoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117437, Russia.
Anastasia A FronyaP.N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119333, Russia.
Egor I MavreshkoP.N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119333, Russia.ORCID 0009-0007-8357-3531 Danila A PokhorukovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117437, Russia.ORCID 0009-0009-5684-0977 Sergey Yu TaskaevBudker Institute of Nuclear Physics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.ORCID 0000-0002-5313-2563 Sergey M DeyevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117437, Russia.ORCID 0000-0002-3952-0631 Irina N ZavestovskayaP.N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119333, Russia.
Funding
Russian Science Foundation 24-62-00018
6 · The paper itselfAbstract
Breast cancer remains one of the most common malignancies worldwide. Highly invasive HER2-positive breast cancer carries a high risk of metastasis and poses a significant therapeutic challenge. Boron neutron capture therapy (BNCT) may be an option for patients with this severe diagnosis. Here we evaluated the effectiveness of BNCT with elemental boron nanoparticles obtained by laser fragmentation and coated Silane-PEG-COOH and conjugated with the Affibody
Indexed as
Affibodyboron neutron capture therapy (BNCT)breast cancerBT-474elemental boron particles (BPs)HER2in vitroin vivomiceSCIDxenografts
Identifiers
PMID42646383
PMCPMC13515628
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