Evidence map›Paper›PMID 42646323›Full record

ArticleMetabolites2026

Guanosine Attenuates Astrocyte-Associated Glutamatergic Dysregulation and Improves Survival in Acute Liver Failure-Induced Hepatic Encephalopathy.

Pedro Arend Guazzelli, Felipe Dos Santos Fachim, Anderson Santos Travassos, Yasmine Nonose, Andréia Silva da Rocha, Francieli Rohden, Fernanda Urruth Fontella, Adriano Martimbianco de Assis, Diogo Onofre Souza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pedro Arend GuazzelliGraduate Program in Biological Sciences: Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre 90035-003, RS, Brazil.
Felipe Dos Santos FachimGraduate Program in Biological Sciences: Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre 90035-003, RS, Brazil.
Anderson Santos TravassosGraduate Program in Biological Sciences: Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre 90035-003, RS, Brazil.
Yasmine NonoseGraduate Program in Biological Sciences: Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre 90035-003, RS, Brazil.
Andréia Silva da RochaGraduate Program in Biological Sciences: Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre 90035-003, RS, Brazil.
Francieli RohdenGraduate Program in Biological Sciences: Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre 90035-003, RS, Brazil.ORCID 0000-0002-9232-7371
Fernanda Urruth FontellaGraduate Program in Biological Sciences: Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre 90035-003, RS, Brazil.
Adriano Martimbianco de AssisGraduate Program in Health and Behaviour, Center of Health Science, Universidade Católica de Pelotas-UCPel, Pelotas 96015-560, RS, Brazil.ORCID 0000-0002-1953-7831
Diogo Onofre SouzaGraduate Program in Biological Sciences: Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre 90035-003, RS, Brazil.

Funding

Brazilian Federal Agency for Support and Evaluation of Graduate Education 88881.083661/2024-01Institutos Nacionais de Ciência e Tecnologia 408446/2024-2National Council for Scientific and Technological Development 312114/2025-7
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acute liver failureastrocytescerebrospinal fluid biomarkersglutamate uptakeguanosinehepatic encephalopathyneuroprotection

Identifiers

PMID42646323
PMCPMC13515678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.