ArticleJournal of xenobiotics2026
Food-Source Patterns and Serum Trace-Metal Biomarkers in the SPES Population Biomonitoring Study, Campania, Italy.
Article in Journal of xenobiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Article
- Serum Trace Elements and Self-Reported Physician-Diagnosed Tumor History: A Secondary Cross-Sectional Analysis of the Exposure Study on Susceptible People (SPES).Medicina (Kaunas, Lithuania) · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundSPES links municipal-cluster biomonitoring with questionnaire data in Campania. We evaluated associations between food-frequency questionnaire (FFQ)-derived food-source patterns, water intake, and serum trace-element biomarkers.
methodsThis cross-sectional analysis included 4137 diet responders. Fifteen food-density groups and water were modelled with covariate adjustment and municipal-cluster random intercepts. Below-LOQ values underwent censoring-aware multiple imputation; false discovery rate (FDR) control was applied within prespecified families. Primary endpoints were Hg-202, As-75, Cd-111, Pb-208, and Ni-60.
resultsFive of 65 primary tests met the FDR threshold. Per interquartile-range (IQR) increase, seafood total density was associated with higher As-75 (geometric mean ratio [GMR] 1.238, 95% CI 1.147-1.335) and Hg-202 (GMR 1.145, 1.084-1.210). Sentinel models showed positive associations of fish and crustaceans/molluscs with As-75 and of fish with Hg-202. Quartile, spline, measured-only, energy-intake, and alcohol-adjusted analyses supported these findings. No association met the FDR threshold for Cd-111, Pb-208, or Ni-60.
conclusionsSeafood intake was associated with total serum Hg-202 and As-75. Because As-75 was non-speciated and may partly reflect recent seafood-derived organic arsenic, its toxicological significance was uncertain. The design did not establish speciation, source, causality, or individual clinical risk.
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