Evidence map›Paper›PMID 42646049›Full record

ArticleJournal of xenobiotics2026

Incidental Changes in Urinary Lead Excretion Following Intra-Venous Ca-DTPA Administration in Patients Treated Primarily for Gadolinium Exposure.

Richard C Semelka, Miguel Ramalho

Abstract read
In one paragraph

Article in Journal of xenobiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Richard C SemelkaRichard Semelka Consulting, PLLC, 3901 Jones Ferry Road, Chapel Hill, NC 27516, USA.ORCID 0000-0001-5773-8071
Miguel RamalhoDepartment of Radiology, Hospital da Luz Lisboa, Avenida Lusíada 100, 1500-650 Lisbon, Portugal.ORCID 0000-0003-2522-1670

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lead is a prevalent environmental pollutant and the heavy metal most frequently associated with toxic effects in humans. This study aimed to evaluate changes in urinary lead excretion following intravenous Ca-DTPA administration. We retrospectively included all patients treated at a medical clinic between January 2023 and March 2025 for suspected symptoms associated with gadolinium exposure who underwent intravenous Ca-DTPA chelation and had both pre- and post-chelation 24 h urine testing for 20 heavy metals. Urinary lead excretion was summarized using mean, standard deviation, median, and interquartile range, and non-parametric testing was applied because values were not normally distributed. A total of 63 participants were included, of whom 37 were female, with a mean age of 48.6 ± 12.5 years, ranging from 15 to 78 years. Median urinary lead excretion increased from 0.283 µg/24 h (IQR, 0.183-0.421) before treatment to 3.22 µg/24 h (IQR, 1.87-5.28) afterward (

Indexed as

agecalcium–DTPAgadolinium exposurelead mobilizationsecondary analysisurinary excretion

Identifiers

PMID42646049
PMCPMC13514330

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.