Evidence map›Paper›PMID 42645955›Full record

ReviewJournal of imaging2026

Quantitative Ultrasound Imaging and Artificial Intelligence in Neonatal Echocardiography: Methodological Advances, Reproducibility Challenges, and Computational Perspectives.

Aikaterini I Nikolaou, Nikitas Chatzigiannis, Maria Alexandra Kefala, Eleni Papaioannou, Maria Baltogianni, Lida-Eleni Giaprou, Vasileios Giapros

Abstract readReview
In one paragraph

Review in Journal of imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aikaterini I NikolaouNeonatal Intensive Care Unit, School of Medicine, University of Ioannina, 45500 Ioannina, Greece.ORCID 0009-0006-9065-7971
Nikitas ChatzigiannisNeonatal Intensive Care Unit, School of Medicine, University of Ioannina, 45500 Ioannina, Greece.
Maria Alexandra KefalaNeonatal Intensive Care Unit, School of Medicine, University of Ioannina, 45500 Ioannina, Greece.
Eleni PapaioannouNeonatal Intensive Care Unit, Hippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.ORCID 0000-0002-4245-1032
Maria BaltogianniNeonatal Intensive Care Unit, School of Medicine, University of Ioannina, 45500 Ioannina, Greece.
Lida-Eleni GiaprouNeonatal Intensive Care Unit, School of Medicine, University of Ioannina, 45500 Ioannina, Greece.
Vasileios GiaprosNeonatal Intensive Care Unit, School of Medicine, University of Ioannina, 45500 Ioannina, Greece.ORCID 0000-0002-5679-3850

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal echocardiography remains an essential imaging modality for the assessment of congenital and hemodynamic cardiovascular abnormalities in critically ill neonates. Recent advances in quantitative ultrasound biomarkers, deformation imaging, volumetric reconstruction, and artificial intelligence (AI)-assisted analysis have substantially expanded the diagnostic capabilities of neonatal cardiovascular ultrasound imaging. This narrative review critically examines current developments in quantitative echocardiographic imaging, advanced volumetric methodologies, and AI-assisted cardiovascular ultrasound analysis, with emphasis on neonatal intensive care applications. A literature search was conducted using PubMed, Google Scholar, Scopus and Embase focusing on neonatal echocardiography, spatiotemporal image correlation (STIC), speckle-tracking echocardiography, artificial intelligence, machine learning, and quantitative cardiovascular imaging. Recent studies suggest that advanced methodologies, including speckle-tracking echocardiography, STIC-based reconstruction, automated segmentation algorithms, and deep learning frameworks, may improve image standardization, automated quantification, and congenital heart disease detection. However, important challenges persist, including operator dependency, dataset heterogeneity, limited external validation, cross-platform variability, and incomplete integration into routine neonatal intensive care workflows. Most AI-assisted echocardiographic systems remain investigational and require further prospective multicenter validation before widespread clinical implementation can be achieved.

Indexed as

artificial intelligencecardiovascular ultrasoundcongenital heart diseasedeep learningmachine learningneonatal echocardiographyneonatal intensive care unitquantitative imaging biomarkersspatiotemporal image correlationspeckle-tracking echocardiography

Identifiers

PMID42645955
PMCPMC13514726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.