Evidence map›Paper›PMID 42645847›Full record

ReviewJournal of cardiovascular development and disease2026

Impact of

Carlos García-Padilla, Estefanía Lozano-Velasco, Virginio García-López, Amelia Aránega, Diego Franco, Virginio García-Martínez, Carmen López-Sánchez

Abstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carlos García-PadillaDepartment of Human Anatomy and Embryology, Faculty of Medicine and Health Sciences, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, Spain.
Estefanía Lozano-VelascoDepartment of Human Anatomy and Embryology, Faculty of Medicine and Health Sciences, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, Spain.ORCID 0000-0002-5615-2754
Virginio García-LópezDepartment of Human Anatomy and Embryology, Faculty of Medicine and Health Sciences, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, Spain.ORCID 0000-0003-1489-7296
Amelia AránegaDepartment of Experimental Biology, University of Jaen, 23071 Jaen, Spain.ORCID 0000-0002-0046-9410
Diego FrancoDepartment of Experimental Biology, University of Jaen, 23071 Jaen, Spain.ORCID 0000-0002-5669-7164
Virginio García-MartínezDepartment of Human Anatomy and Embryology, Faculty of Medicine and Health Sciences, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, Spain.ORCID 0000-0002-7760-1985
Carmen López-SánchezDepartment of Human Anatomy and Embryology, Faculty of Medicine and Health Sciences, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, Spain.ORCID 0000-0003-3296-2071

Funding

Government of Extremadura GR24140
6 · The paper itself

Abstract

Cardiogenesis begins during gastrulation with the bilateral specification of precardiac mesoderm on either side of the embryo. These fields fuse at the embryonic midline to form the linear heart tube, which subsequently undergoes rightward looping and chamber formation. Expansion and septation of the primitive atrial and ventricular chambers establish separate systemic and pulmonary circuits with correctly aligned inflow and outflow tracts. These morphogenetic events depend on the coordinated activation and repression of cell type-specific cardiac gene programmes controlled at transcriptional and post-transcriptional levels by cardiac transcription factors and paracrine/autocrine signals. Non-coding RNAs, particularly microRNAs and long non-coding RNAs, add an essential regulatory layer. MicroRNAs are endogenous ≈22-nt RNAs that modulate gene expression predominantly at the post-transcriptional level. The muscle-enriched

Indexed as

cardiac developmentcardiogenesisheart diseasesheart failuremiR-1/miR-133 cluster

Identifiers

PMID42645847
PMCPMC13513748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.