ArticleJournal of cardiovascular development and disease2026
Heart Rate Influences the Relationship Between Heart Rate Variability and Ventricular Repolarization in Children: A 24-h Holter Study.
Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesHeart rate variability (HRV) and ventricular repolarization are key noninvasive markers of cardiac autonomic regulation and electrical stability. Their physiological relationship in healthy pediatric populations remains incompletely understood. This study evaluated the association between HRV parameters and ventricular repolarization indices and established age-specific reference values for HRV.
methodsThis cross-sectional study included 254 healthy children (5-18 years) who underwent 24 h Holter monitoring. HRV parameters (SDNN, SDANN, RMSSD, pNN50, LF, HF, LF/HF ratio) and repolarization indices (QT, QTc, QTd, QTcd) were analyzed. Age-stratified percentile distributions were generated, and multivariable analyses were performed, adjusting for age, sex, and heart rate.
resultsAll HRV parameters increased significantly with age (
conclusionIn healthy children, the apparent association between HRV and the QT interval appears to be largely explained by heart rate rather than by an independent physiological relationship. These findings highlight the importance of considering heart rate when interpreting associations between autonomic and ventricular repolarization parameters in pediatric studies. Age-specific HRV reference values may support the clinical interpretation of pediatric autonomic and electrophysiological assessments.
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