Evidence map›Paper›PMID 42645844›Full record

ArticleJournal of cardiovascular development and disease2026

Tetranectin as a Potential Biomarker Associated with Post-Operative Inotropic Support Following the Norwood Procedure in Neonates: A Pilot Study.

Ananya Manchikalapati, Namasivayam Ambalavanan, Akm F Rahman, Inmaculada Aban, Brian A Halloran, Kristal M Hock, Michele Kong, Santiago Borasino, Ahmed Asfari

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Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ananya ManchikalapatiDepartment of Pediatrics, Division of Critical Care, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Namasivayam AmbalavananDepartment of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-0731-9092
Akm F RahmanDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Inmaculada AbanDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Brian A HalloranDepartment of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-4259-4524
Kristal M HockDepartment of Pediatrics, Division of Cardiology, Section of Cardiac Critical Care, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-4301-3616
Michele KongDepartment of Pediatrics, Division of Critical Care, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Santiago BorasinoDepartment of Pediatrics, Division of Cardiology, Section of Cardiac Critical Care, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Ahmed AsfariDepartment of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTetranectin (TN) is a protein that plays a role in tissue remodeling. In adults with heart failure, TN has a better prognostic value compared to B-type natriuretic peptide (BNP). We aimed to examine changes in TN in neonates following the Norwood operation and explore its prognostic value.

methodsRetrospective observational pilot cohort study in a tertiary pediatric cardiac intensive care unit. Neonates who underwent the Norwood procedure and had stored plasma samples in our biorepository were screened for inclusion. TN and BNP levels were measured by ELISA at five different time points in relation to cardiopulmonary bypass (CPB) in 26 neonates who met the inclusion criteria. The primary outcomes were time to lactate clearance and duration of inotropic support.

resultsUnivariate analysis showed that higher TN levels at 0 and 4 h were associated with a longer duration of inotropic support. Logistic regression analyses comparing TN levels at different time points with duration of inotropic support showed that TN level at 4 h post-CPB was a significant predictor (

conclusionsIn this pilot cohort, higher observed TN concentrations in the early post-operative period were associated with longer duration of inotropic support. TN was not found to be significantly associated with time to lactate clearance. These exploratory findings require validation in larger prospective studies before TN can be considered for clinical prognostication.

Indexed as

biomarkercardiac surgerylow cardiac output stateNorwood procedureTetranectin

Identifiers

PMID42645844
PMCPMC13513037

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