ArticleJournal of cardiovascular development and disease2026
Indobufen Versus Aspirin After CABG for Unstable Angina in Patients Aged 70 Years and Older.
Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPostoperative antiplatelet selection after coronary artery bypass grafting (CABG) in adults aged ≥70 years requires balancing ischemic protection against bleeding risk.
methodsWe conducted a single-center retrospective cohort study of adults aged ≥70 years who underwent isolated CABG for unstable angina between 2017 and 2021. The exposure was the initial discharge antiplatelet pathway: aspirin 100 mg once daily or indobufen 100 mg twice daily as the cyclooxygenase-inhibitor component, combined with a P2Y12 inhibitor during the first postoperative year and followed by the same cyclooxygenase inhibitor during the second year. Propensity scores were estimated using multivariable logistic regression with 16 prespecified baseline covariates, and stabilized inverse probability of treatment weighting (IPTW) was applied. The primary analyses used IPTW-weighted Cox models.
resultsAmong 336 screened patients, 79 were included in the final analytic cohort (aspirin-based pathway,
conclusionsIn this real-world cohort of older patients undergoing CABG for unstable angina, an initial indobufen-based discharge pathway was not statistically significantly associated with 24-month MACCE, BARC grade ≥2 bleeding, or NACE compared with an aspirin-based pathway after stabilized IPTW. These findings add exploratory CABG-specific data on indobufen in older patients and should be confirmed in larger prospective studies.
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