ReviewInfectious disease reports2026
Application of Outer Membrane Protein Omp25 in Serological Diagnosis of Brucellosis.
Review in Infectious disease reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
backgroundBrucellosis remains a widespread zoonotic disease where serodiagnosis is critical for control. Outer membrane protein 25 (Omp25) has emerged as a promising diagnostic antigen, yet the optimal antigen format for Omp25-based serological assays remains unclear.
methodsWe performed a systematic review and meta-analysis of diagnostic accuracy studies following PRISMA-DTA 2020 guidelines. Four electronic databases were searched through July 16, 2026. Risk of bias was assessed using QUADAS-2. Diagnostic accuracy was synthesized using the bivariate binomial model, with subgroup analyses stratified by host species and antigen format.
resultsTen diagnostic accuracy studies comprising 23 study arms were included. Substantial heterogeneity was observed (I
conclusionsMulti-protein antigen formats offer more consistent diagnostic reliability than monomeric Omp25 for brucellosis serodiagnosis, though performance varies significantly by host species. Clinical translation requires standardized antigen preparation protocols, uniform reference standards, and cautious species-specific application. Future research should prioritize larger, species-stratified, multi-center validation and prospective trials to establish Omp25-based DIVA capability.
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