Evidence map›Paper›PMID 42645799›Full record

ReviewHematology reports2026

A Narrative Review of Zinc Deficiency-Associated Anemia.

Karina Basmajian, Aren Dermarderosian, Ryan Jeffrey Thoreson, Joshua Adams, Camron Farjami, Austin Yang, Elham Akhtari, Soha Araji, Ziad Khan, Siamak Saadat and 4 more

Abstract readReview
In one paragraph

Review in Hematology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Karina BasmajianDepartment of Internal Medicine, Arrowhead Regional Medical Center, Colton, CA 92324, USA.
Aren DermarderosianUniversity of California, Davis, School of Medicine, Sacramento, CA 95817, USA.ORCID 0009-0001-9038-8752
Ryan Jeffrey ThoresonSouthern Methodist University, Dallas, TX 75205, USA.
Joshua AdamsCalifornia University of Science of Medicine, Colton, CA 92324, USA.ORCID 0009-0002-4503-2543
Camron FarjamiPalos Verdes Peninsula High School, Rolling Hills Estates, CA 90274, USA.ORCID 0009-0007-9651-9681
Austin YangUniversity of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0005-9501-9226
Elham AkhtariDepartment of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.
Soha ArajiDepartment of Pharmacy, Sharp Healthcare, San Diego, CA 92110, USA.
Ziad KhanDepartment of Medicine, Division of Hematology/Oncology, Arrowhead Regional Medical Center, Colton, CA 92324, USA.
Siamak SaadatDepartment of Medicine, Division of Hematology/Oncology, Arrowhead Regional Medical Center, Colton, CA 92324, USA.
Sarkis ArabianDepartment of Medicine, Division of Pulmonology/Critical Care, Arrowhead Regional Medical Center, Colton, CA 92324, USA.
Christina TansyDepartment of Medicine, Division of Hematology/Oncology, Arrowhead Regional Medical Center, Colton, CA 92324, USA.
Gregory KnutzenDepartment of Medicine, Division of Hematology/Oncology, Arrowhead Regional Medical Center, Colton, CA 92324, USA.
Mojtaba AkhtariDepartment of Medicine, Division of Transplantation, Cellular Therapy, and Hematological Malignancies, Loma Linda University School of Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc is an essential micronutrient involved in many physiological processes in the human body, including immune system regulation, cellular survival, neurologic function, and erythropoiesis. Zinc deficiency can result in a wide range of clinical manifestations, including impaired immune function, dermatologic findings, and decreased growth. Anemia has been reported as a hematologic manifestation of zinc deficiency and may be underrecognized in clinical practice. This narrative review examines the pathophysiology of zinc deficiency-associated anemia, highlighting zinc's role in erythropoiesis, heme biosynthesis, and red blood cell stability. It also outlines populations at increased risk for zinc deficiency, including patients with chronic kidney disease, sickle cell disease, malabsorptive disorders, chronic proton pump inhibitor use, and older adults. Emerging evidence suggests that zinc deficiency-associated anemia may represent a potentially modifiable contributor to anemia in selected at-risk populations, although the strength of evidence varies across clinical settings and study designs. Assessment of zinc status may be considered in patients with unexplained or refractory anemia and additional risk factors for deficiency. Further prospective studies are needed to clarify the role of zinc deficiency in anemia and define appropriate screening, supplementation, and monitoring strategies.

Indexed as

anemiarefractory anemiazinc deficiencyzinc deficiency-associated anemiazinc supplementation

Identifiers

PMID42645799
PMCPMC13512597

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.