Evidence map›Paper›PMID 42645790›Full record

ArticleHematology reports2026

Complexities in the Diagnostic Evaluation and Treatment of Infant Hemophagocytic Lymphohistiocytosis.

Reeja Raj, Ramya Ramakrishnan, Carlos Vargas, Muhammad Khalid, Gopi Mohan, David McCall, Amber Gibson, Branko Cuglievan, Cesar Nunez, Brandon Brown and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Hematology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Reeja RajDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1487, Houston, TX 77030, USA.ORCID 0009-0003-8336-8766
Ramya RamakrishnanDepartment of Pediatrics, Oklahoma University Health Sciences Center, 1100 N Lindsay Ave., Oklahoma City, OK 73104, USA.
Carlos VargasDepartment of Pediatrics, Texas Children's Hospital, 6701 Fannin St., Houston, TX 77030, USA.ORCID 0009-0001-8002-1455
Muhammad KhalidDepartment of Pathology and Laboratory Medicine, McGovern Medical School, UTHealth, 64313 Fannin St., Houston, TX 77030, USA.ORCID 0009-0008-4796-185X
Gopi MohanDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1487, Houston, TX 77030, USA.ORCID 0000-0002-8204-9769
David McCallDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1487, Houston, TX 77030, USA.ORCID 0000-0003-2297-9670
Amber GibsonDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1487, Houston, TX 77030, USA.ORCID 0000-0002-9146-4702
Branko CuglievanDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1487, Houston, TX 77030, USA.
Cesar NunezDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1487, Houston, TX 77030, USA.
Brandon BrownDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1487, Houston, TX 77030, USA.
Monica BrayDepartment of Pediatrics, McGovern Medical School, UTHealth, 64313 Fannin St., Houston, TX 77030, USA.
Miriam B GarciaDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1487, Houston, TX 77030, USA.ORCID 0000-0002-2978-2267

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Clinical Significance: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by excessive activation of the immune system. Case Presentation: We present the case of an eight-month-old infant with influenza A(H1N1) who presented with seizures, hepatosplenomegaly, cytopenias, and markedly elevated levels of ferritin, IL-18, and CXCL9, raising concern for HLH. Despite initiation of HLH-directed and antiviral therapy, she succumbed to cardiorespiratory failure. Genetic testing revealed heterozygous variants in

Indexed as

geneticshemophagocytic lymphohistiocytosisimmune dysregulationimmunomodulationpediatrics

Identifiers

PMID42645790
PMCPMC13511909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.