Evidence map›Paper›PMID 42645789›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2026

Observation of the Cryoprotective Effect of Chlorogenic Acid on Spermatogonial Stem Cells Transplanted into of Testicular Torsion-Induced Azoospermia Model.

Sareh Khoshbakht, Azim Hedayatpour, Tayebeh Rastegar, Alireza Ebrahimzade Bideskan, Mohsen Mir, Mohammadreza Ebrahimzade, Samiullah Safi, Farnaz Khadivi

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In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sareh KhoshbakhtDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Azim HedayatpourDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. hedayatpour@tums.ac.ir.ORCID http://orcid.org/0000-0001-8509-9764
Tayebeh RastegarDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Alireza Ebrahimzade BideskanDepartment of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohsen MirDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadreza EbrahimzadeDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Samiullah SafiDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Farnaz KhadiviDepartment of Anatomy, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preserving spermatogonial stem cells (SSCs) in prepubertal males, followed by long-term cryostorage for future autologous transplantation, is a promising strategy for managing male infertility. This study investigated the effects of chlorogenic acid (CGA), an antioxidant agent, on SSCs maintained in a basal cryopreservation medium, aiming to evaluate its potential role in supporting cellular preservation under storage conditions. A torsion/detorsion protocol was applied to induce azoospermia in a murine model. Mice were randomized into five groups: fresh SSC transplantation, SSC transplantation with CGA, SSC transplantation using basal cryopreservation medium, a control group, and an untreated azoospermia group. Eight weeks post-transplantation, SSC proliferation and differentiation were assessed using specific markers. In addition, the expression of apoptosis-associated genes (Bax and Bcl-2), components of the PI

Indexed as

Adult Germline Stem CellsAzoospermiaChlorogenic AcidCryopreservationCryoprotective AgentsSpermatic Cord TorsionSpermatogoniaStem Cell TransplantationAnimalsApoptosisCell DifferentiationCell ProliferationDisease Models, AnimalMaleMiceChlorogenic AcidCryoprotective AgentsChlorogenic acidMale infertilitySpermatogonial stem cellTesticular torsionTransplantation

Identifiers

PMID42645789

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.