Evidence map›Paper›PMID 42645765›Full record

ReviewGeroScience2026

Calcium dysregulation in neurovascular function in Alzheimer's disease: mechanisms, therapeutic targets.

Yvan Hanscom-Trofy, Andrew Gregory, Gilbert C Morgan, Hongwei Yu, Rui Dong, Fan Fan

Abstract readReview
PubMed Publisher
In one paragraph

Review in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yvan Hanscom-TrofyDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Andrew GregoryDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Gilbert C MorganDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Hongwei YuAnesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Rui DongDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA. RUDONG@augusta.edu.
Fan FanDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA. ffan@augusta.edu.

Funding

American Heart Association 25PRE1365157Medical College of Georgia, Augusta University TRIBA/ Physiology Faculty Startup FundNIA NIH HHS AG094068NIH AG057842NIH AG079336
6 · The paper itself

Abstract

Neurovascular dysfunction, characterized by impaired cerebral blood flow (CBF) autoregulation and neurovascular coupling (NVC), represents a critical upstream facilitator of Alzheimer's disease (AD) that precedes overt cognitive decline. While traditional therapeutic strategies that focus strictly on amyloid β clearance have achieved limited long-term clinical efficacy, targeting the mechanisms governing neurovascular uncoupling offers a promising frontier. Calcium ions (Ca

Indexed as

Alzheimer’s diseaseBlood–brain barrierCalcium signalingCerebral blood flow autoregulationNeurovascular couplingTherapeutic targets

Identifiers

PMID42645765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.