ArticleOdontology2026
Laminarin attenuates irradiation-induced salivary gland hypofunction in mice: association with enhanced Nrf2-associated antioxidant responses.
Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy-induced salivary gland (SG) hypofunction substantially impairs the quality of life for patients with head and neck cancer, while effective preventive treatments remain limited. This study investigated the protective effects of laminarin against SG injury in mice and its association with Nrf2-related antioxidant responses. Mice received a single 15-Gy head and neck irradiation and were assessed 28 days later. Body weight, food and water intake, stimulated salivary flow rate, submandibular gland weight, histopathological changes, AQP5 expression, oxidative stress indicators, and Nrf2-associated proteins were evaluated. Irradiation reduced body weight, food intake, SG weight, salivary secretion, and AQP5 expression, while increasing water intake, histopathological injury, ROS, and MDA levels. Laminarin ameliorated these changes, preserved SG function, increased MnSOD expression, and reduced oxidative stress. Laminarin treatment was also accompanied by higher nuclear Nrf2 protein levels and increased HO-1 and NQO1 expression. These findings indicate that laminarin attenuates irradiation-induced SG hypofunction and oxidative injury in mice and suggest a possible association with enhanced Nrf2-associated antioxidant responses. The present study provides preclinical evidence supporting further evaluation of laminarin as a potential radioprotective strategy for preserving SG function during head and neck radiotherapy.
Indexed as
Identifiers
42645740What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.