The cGAS-STING pathway in inflammaging and neuroinflammation.

Chufan Zhang, Chaxian Liu, Yingbo Zhao, Hanze Wang, Ziyuan Fang, Ziqian He, Ying Mao, Hui Yang

Abstract readReview

In one paragraph

Review in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chufan Zhang *Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Chaxian Liu *Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Yingbo Zhao *Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Hanze Wang *Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Ziyuan Fang *Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Ziqian HeDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA.

Ying MaoDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200032, China. maoying@fudan.edu.cn.

Hui YangDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200032, China. hui_yang@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytosolic DNA surveillance through the cGAS-STING axis is a central component of innate immune defense, coupling the detection of mislocalized DNA to downstream inflammatory responses. Beyond its established role in antiviral immunity, dysregulated cGAS-STING signaling has emerged as an important driver of cellular senescence, chronic sterile inflammation, and the progression of aging-associated disorders, particularly in the central nervous system. In this review, we integrate recent advances in understanding the multilayered regulation of cGAS-STING signaling, its expanding roles in inflammaging and neuroinflammation, and current therapeutic strategies aimed at modulating this pathway to re-establish immune homeostasis in diseases linked to chronic inflammation and neuroimmune dysfunction.

Indexed as

cGAS-STING signalinginflammaginginnate immunityneuroinflammation

Identifiers

PMID42645680

DOI10.1016/j.cell.2019.05.035

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.