Evidence map›Paper›PMID 42645565›Full record

ArticleJournal of molecular histology2026

Changes in the minor salivary glands and ductal carcinoma resulting from induction of oral carcinogenesis.

Caio Rodrigues Maia, Raissa Cláudia Eufrázio de Oliveira, Viviane Tainá Carvalho da Silva, Cecília Cerqueira Souza, Vivian Gracielly Nascimento de Oliveira, Alana Beatriz Brito Costa, Pedro Paulo de Andrade Santos

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Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Caio Rodrigues MaiaFederal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Raissa Cláudia Eufrázio de OliveiraFederal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Viviane Tainá Carvalho da SilvaFederal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Cecília Cerqueira SouzaFederal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Vivian Gracielly Nascimento de OliveiraFederal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Alana Beatriz Brito CostaFederal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Pedro Paulo de Andrade SantosDepartment of Morphology - Biosciences Center, Federal University of Rio Grande do Norte (UFRN), Campus Universitário, Lagoa Nova, Natal, RN, 59078-900, Brasil. pedro.paulo.santos@ufrn.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the scarcity of experimental studies on the effects of induced oral carcinogenesis on the minor salivary glands, the aim of this study was to analyze the histopathological changes present in the lingual and palatal minor salivary glands (MiSGs) resulting from 4NQO exposure in rats from the 8th to the 30th week of the experiment. Eleven rats were used in the control group and 45 rats in the experimental groups that received 4NQO/propylene glycol diluted in drinking water. Histopathological analysis revealed evidence of hyperplasia, metaplasia, and ductal dysplasia, saliva buildup in the ducts, inflammatory infiltrate, lobular atrophy, degeneration of the secretory portion, fibrosis/replacement, and invasion of the minor salivary glands. The most evident change in both tongue and palate MiSGs was degeneration of the secretory portion, which reduced salivation and promoted the oncogenic action of 4NQO. However, changes such as hyperplasia, metaplasia, and dysplasia, which may promote the development of neoplastic changes, were more prevalent in tongue MiSGs. In the present study, we also identified an incidental case of salivary ductal carcinoma in palatal MiSGs. Given this, it is important to be vigilant regarding potential changes in MiSGs, as they may be related to the development of malignancies.

Indexed as

CarcinogenesisCarcinoma, DuctalMouth NeoplasmsSalivary Gland NeoplasmsSalivary Glands, Minor4-Nitroquinoline-1-oxideAnimalsMaleRats4-Nitroquinoline-1-oxide4NQODuctal carcinomaPalatine salivary glandsSquamous cell carcinomaTongue salivary glands

Identifiers

PMID42645565
PMCPMC13518474

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.