ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026
Association between the LDL-C/TG ratio and scoliosis: a retrospective cross‑sectional study.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the association between the low‑density lipoprotein cholesterol to triglyceride (LDL‑C/TG) ratio and the severity of spinal deformity in a surgical population.
methodsThis retrospective cross‑sectional study analyzed 166 patients undergoing spinal surgery. Scoliosis severity was defined by the Cobb angle. Multivariable logistic regression models were constructed to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines (RCS) were used to characterize dose‑response relationships. Receiver operating characteristic (ROC) curves and decision curve analysis (DCA) were performed to assess discriminative ability and clinical utility. Sensitivity analyses were conducted using a 20° threshold and by excluding participants younger than 18 years.
resultsA total of 166 participants were enrolled, with 71 (42.77%) in the higher Cobb angle group (≥ 19.71°). The LDL‑C/TG ratio was significantly associated with scoliosis severity. In the model 2, each 1‑unit increase in the ratio correlated with an 148% higher risk (OR = 2.48, 95% CI: 1.09-5.62). The third quartile (Q3) showed a 307% higher risk compared to the lowest (Q1) (OR = 4.07, 95% CI: 1.44-11.51). RCS confirmed a dose‑response relationship (P = 0.027). The ratio demonstrated modest discriminatory performance (AUC = 0.67) and provided a higher net benefit than default strategies.
conclusionsThe LDL‑C/TG ratio is significantly associated with spinal deformity severity and may serve as a potential indicator for risk stratification. Further prospective studies are needed to validate these findings.
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