Evidence map›Paper›PMID 42645538›Full record

ArticleNeuroradiology2026

Spontaneous regression of Rathke's cleft cysts: MRI predictors and temporal dynamics.

Jianrui Li, Liuwei Guo, Jun Bi, Zixiang Cong, Jing Li, Ruifeng Wang, Ya Liu, Hao Tang, Jing Sun, Sui Chen and 2 more

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In one paragraph

Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Jianrui Li *Department of Medical Imaging, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China.
Liuwei Guo *Department of Medical Imaging, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China.
Jun BiDepartment of Medical Imaging, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China.
Zixiang CongDepartment of Neurosurgery, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China.
Jing LiDepartment of Radiation Oncology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China.
Ruifeng WangDepartment of Endocrinology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China.
Ya LiuDepartment of Medical Imaging, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China.
Hao TangDepartment of Medical Imaging, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China.
Jing SunDepartment of Medical Imaging, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China.
Sui ChenDepartment of Medical Imaging, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China. chensui30000@163.com.
Qirui ZhangDepartment of Neurology, Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA. Qirui.Zhang@jefferson.edu.ORCID https://orcid.org/0000-0002-3520-9336
Xiaoqing ChengDepartment of Medical Imaging, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing University, Nanjing, China. rabbitkiller80@126.com.

Funding

the Nanjing Jinling Hospital Management Research Project 22LCZLXJS51the National Natural Science Foundation of China 82271983
6 · The paper itself

Abstract

purposeTo identify objective MRI features predictive of spontaneous regression in Rathke's cleft cysts (RCCs) under active surveillance and to develop a predictive model based on these features.

methodsThis retrospective study included 161 patients with RCCs managed with active surveillance (30 with regression, defined as volume reduction ≥25% or disappearance; 131 without). MRI at 3.0 T (including T1-weighted, T2-weighted, and dynamic contrast-enhanced sequences) was independently evaluated by two neuroradiologists blinded to clinical data, time sequence, and group assignment. Multivariable logistic regression and Cox proportional hazards models were used to identify predictors, with model discrimination assessed using Harrell's C-index and time-dependent AUC (Area under the curve).

resultsMaximum cyst diameter was a significant predictor of regression (OR per mm = 1.24; HR = 1.27). Intracystic nodules were significant in logistic regression (OR = 3.80) but not in the time-dependent Cox model (HR = 1.92). Optic chiasm compression showed a negative association, significant in the Cox model (HR = 0.10). The combined model (diameter + nodules + compression) achieved significant discriminatory ability (C-index = 0.761), with higher discriminative performance during the 500-800 day follow-up interval.

conclusionsA maximum cyst diameter greater than 8 mm and intracystic nodules are associated with spontaneous RCC regression, suggesting that cysts with these features may warrant increased clinical attention within the first 500-800 days of surveillance, though specific follow-up strategies require prospective validation.

Indexed as

Active surveillanceMagnetic resonance imagingRathke's cleft cystSpontaneous regressionTemporal dynamics

Identifiers

PMID42645538

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