Evidence map›Paper›PMID 42645386›Full record

ArticleCurrent oncology (Toronto, Ont.)2026

Intraoperative Neurophysiological Monitoring During Adult Brainstem Glioma Resection: Association Between Electrophysiological Changes and Early Neurological Outcome.

Giada Pauletto, Benjamin Skrap, Barbara Tomasino, Christian Lettieri, Elisa Ecoretti, Miran Skrap, Andrea Landi, Luca Denaro, Marco Vindigni, Massimo Robiony and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giada PaulettoNeurology Unit, Head-Neck and Neuroscience Department, Santa Maria della Misericordia University Hospital, 33100 Udine, Italy.ORCID 0000-0002-8875-6640
Benjamin SkrapNeurosurgery Unit, Head-Neck and Neuroscience Department, Santa Maria della Misericordia University Hospital, 33100 Udine, Italy.
Barbara TomasinoScientific Institute, IRCCS E. Medea, 33037 Pasian di Prato, Italy.ORCID 0000-0003-3135-2984
Christian LettieriClinical Neurology Unit, Head-Neck and Neuroscience Department, Santa Maria della Misericordia University Hospital, 33100 Udine, Italy.ORCID 0000-0002-8140-6277
Elisa EcorettiNeurophysiology Unit, Head-Neck and Neuroscience Department, Santa Maria della Misericordia University Hospital, 33100 Udine, Italy.
Miran SkrapIndependent Researcher, 34151 Trieste, Italy.
Andrea LandiAcademic Neurosurgery, Department of Neurosurgery, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-7185-7779
Luca DenaroAcademic Neurosurgery, Department of Neurosurgery, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-2529-6149
Marco VindigniNeurosurgery Unit, Head-Neck and Neuroscience Department, Santa Maria della Misericordia University Hospital, 33100 Udine, Italy.
Massimo RobionyClinical Unit of Maxillofacial Surgery, Head-Neck and Neuroscience Department, Santa Maria della Misericordia University Hospital, 33100 Udine, Italy.
Mariarosaria ValenteClinical Neurology Unit, Head-Neck and Neuroscience Department, Santa Maria della Misericordia University Hospital, 33100 Udine, Italy.
Tamara IusAcademic Neurosurgery, Department of Neurosurgery, University of Padova, 35128 Padova, Italy.
Lorenzo VerrielloNeurology Unit, Head-Neck and Neuroscience Department, Santa Maria della Misericordia University Hospital, 33100 Udine, Italy.ORCID 0000-0002-5301-8621

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraoperative neurophysiological monitoring (IONM) is widely used during brainstem surgery to reduce the risk of neurological injury, although its prognostic value in adult brainstem glioma (BSG) surgery remains unclear. We retrospectively analyzed 22 consecutive adults who underwent surgery for BSGs with multimodal IONM between 2010 and 2023. Monitoring included somatosensory evoked potentials (SSEPs), motor evoked potentials (MEPs), brainstem auditory evoked potentials (BAEPs), corticobulbar MEPs (CoMEPs), and cranial nerves electromyography. The primary endpoint was the association between intraoperative neurophysiological changes and postoperative neurological functional status at hospital discharge, assessed with the modified McCormick Scale (mMCS). Secondary endpoints included postoperative complications and length of hospital stay. SSEP warning criteria were met in 10 patients (45.5%), while 10 patients (45.5%) experienced a ≥50% reduction in MEP amplitude in at least one monitored muscle. Despite these findings, neither SSEP nor MEP amplitude changes were significantly associated with postoperative neurological status. Transcranial MEP stimulation thresholds increased significantly during surgery (

Indexed as

Brain Stem NeoplasmsGliomaIntraoperative Neurophysiological MonitoringAdultAgedElectromyographyEvoked Potentials, Auditory, Brain StemEvoked Potentials, MotorEvoked Potentials, SomatosensoryFemaleHumansMaleMiddle AgedRetrospective Studiesadult brainstem gliomabrainstem surgeryintraoperative neurophysiological monitoringMEP stimulation thresholdneurological outcome

Identifiers

PMID42645386
PMCPMC13511618

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.