ArticleCurrent oncology (Toronto, Ont.)2026
Prognostic Value of Immunonutritional Status and Radiologic Muscle Mass in Older Patients Receiving Immune Checkpoint Inhibitors: A Real-World Study.
Article in Current oncology (Toronto, Ont.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIdentifying biomarkers for biological vulnerability in older patients with cancer remains challenging. We evaluated psoas muscle index (PMI) and immunonutritional indices' association with toxicity and overall survival (OS) in patients ≥ 65 years receiving immune checkpoint inhibitors (ICIs).
methodsThis retrospective study included 104 patients. Baseline sarcopenia was assessed via CT-derived PMI at the L3 level. Immunonutritional status was evaluated using the Prognostic Nutritional Index (PNI). Primary endpoint was immune-related adverse event (irAE) development; secondary endpoint was OS.
resultsMedian age was 71 years. Patients developing irAEs had significantly higher baseline PNI than those without (49.0 vs. 46.0,
conclusionsBaseline PNI was independently associated with OS, whereas PMI was not significantly associated with survival in this cohort. These findings support the potential prognostic utility of PNI in older patients receiving immunotherapy but should not be interpreted as demonstrating superiority over comprehensive sarcopenia assessment.
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