ReviewBiomimetics (Basel, Switzerland)2026
Mitigating Monomer Leaching and Resin-Related Hypersensitivity in Removable Orthodontics Through Bio-Inspired Surface Modifications: A Narrative Review.
Review in Biomimetics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring clinical service, removable orthodontic appliances are continuously exposed to environmental challenges that may compromise material stability and contribute to potentially increasing the risk of local inflammatory responses and hypersensitivity reactions.
methodA literature search was conducted using PubMed/MEDLINE, Scopus, and Web of Science databases. Studies investigating bio-inspired and surface-engineering approaches applicable to orthodontic polymers, acrylic resins, aligner materials, and related dental biomaterials were considered. Evidence from orthodontic adhesives and non-bio-inspired barrier coatings was included when relevant as comparative or translational support. Particular attention was given to polydopamine coatings, polyphenol- and tannic acid-based coatings, chitosan systems, peptide-functionalized surfaces, titanium and titanium oxide-based modifications, nanoparticle-enriched coatings, biomimetic hydrogel-like barriers, and conventional barrier coatings used as comparators.
resultsAvailable evidence suggests that surface modifications reduce monomer diffusion, bacterial adhesion, biofilm formation, and improve cellular responses. Bio-inspired and titanium-based coatings show particular promise by enhancing biocompatibility while providing antimicrobial, antioxidant, anti-inflammatory, and protective barrier properties. Conclusions Bio-inspired surface engineering is a promising approach to improve the biological safety of removable orthodontic appliances. However, further standardized in vitro, in situ, and clinical studies are needed to confirm their long-term stability, durability, and clinical effectiveness in reducing hypersensitivity and other adverse biological effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.