Evidence map›Paper›PMID 42645216›Full record

ArticleCells2026

Stage-Dependent Transmural Redistribution of NET-Associated Structures and Altered DNA Architecture in Acute Appendicitis.

Jonas Pachmann, Malik Szep, Pia Meyer Zu Himmern, Max Rickes, Sara Al-Madhi, Mihailo Andric, Mirhasan Rahimli, Jessica Stockheim, Katrin Hippe, Franziska S Karras and 4 more

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jonas PachmannMolecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine and University Hospital Magdeburg, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0009-0008-8358-6903
Malik SzepMolecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine and University Hospital Magdeburg, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Pia Meyer Zu HimmernMolecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine and University Hospital Magdeburg, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0009-0007-2457-899X
Max RickesMolecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine and University Hospital Magdeburg, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Sara Al-MadhiUniversity Clinic for General, Visceral, Vascular and Transplantation Surgery, Faculty of Medicine, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0009-0006-3633-5322
Mihailo AndricUniversity Clinic for General, Visceral, Vascular and Transplantation Surgery, Faculty of Medicine, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Mirhasan RahimliUniversity Clinic for General, Visceral, Vascular and Transplantation Surgery, Faculty of Medicine, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0000-0002-6708-6596
Jessica StockheimMolecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine and University Hospital Magdeburg, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0000-0002-8962-6784
Katrin HippeInstitute of Pathology, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Franziska S KarrasInstitute of Pathology, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0009-0009-5621-2321
Ulf D KahlertMolecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine and University Hospital Magdeburg, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0000-0002-6021-1841
Roland S CronerMolecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine and University Hospital Magdeburg, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0000-0001-6248-7086
Martin HerrmannMolecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine and University Hospital Magdeburg, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Maximilian DöllingMolecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine and University Hospital Magdeburg, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0000-0002-0303-1342

Funding

Polycarp-Leporin Program PLP25/2
6 · The paper itself

Abstract

Neutrophil extracellular traps (NETs) contribute to antimicrobial defense but may promote tissue damage when produced in excess or insufficiently cleared. Acute appendicitis is characterized by neutrophil-driven inflammation, but NET-associated structures and their compartment-specific dynamics have not yet been systematically evaluated. We analyzed appendiceal tissue across histopathological stages of adult appendicitis patients (

Indexed as

AppendicitisDNAExtracellular TrapsAcute DiseaseAdultFemaleHistonesHumansMaleMiddle AgedNeutrophilsPeroxidaseDNAHistonesPeroxidaseacute appendicitiscfDNAcitrullinated histone H3complicated appendicitisDNA architecturemodified DNAmyeloperoxidaseneutrophil extracellular traps (NETs)

Identifiers

PMID42645216
PMCPMC13511748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.