Evidence map›Paper›PMID 42645201›Full record

ArticleCells2026

A Regulatory Element in the Intrinsically Disordered C-Terminal Region of LMTK3 Modulates Its Kinase Domain Interactions and Breast Cancer Phenotypes.

Andrea Lauer Betrán, Alessandro Agnarelli, Mark Samuels, Viviana Vella, Reza Shirazi Nia, Daniel De Vega, Niloufar Poudine, Daniela Carter-Lopez, Angeliki Ditsiou, Murat Eravci and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andrea Lauer BetránDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.ORCID 0009-0003-5191-1015
Alessandro AgnarelliDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.ORCID 0000-0003-3218-3836
Mark SamuelsDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.
Viviana VellaDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.ORCID 0000-0003-1000-3443
Reza Shirazi NiaInternational Oncology Institute, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China.ORCID 0000-0003-4002-4712
Daniel De VegaInternational Oncology Institute, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China.
Niloufar PoudineInternational Oncology Institute, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China.
Daniela Carter-LopezDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.ORCID 0009-0006-6645-6125
Angeliki DitsiouDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.ORCID 0000-0003-3743-8447
Murat EravciDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.ORCID 0000-0003-4786-9179
Chrisostomos ProdromouDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.ORCID 0000-0003-4320-1147
Erika J ManciniSussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.ORCID 0000-0001-9591-7898
Georgios GiamasDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.ORCID 0000-0002-4417-2707

Funding

action against cancer G1868
6 · The paper itself

Abstract

Lemur tail kinase 3 (LMTK3) is an oncogenic Ser/Thr kinase implicated in breast cancer (BC) progression, therapy resistance, and poor clinical outcomes, yet the molecular mechanisms governing its regulation remain poorly understood, particularly the role of its C-terminal intrinsically disordered region (IDR). Given that IDRs frequently harbour hidden structural motifs that control protein dynamics, we combined computational, biophysical, and biochemical approaches to systematically map regulatory elements within the LMTK3 C-terminus, identifying two regions (residues 688-1095 and 1181-1486) that interact with the LMTK3 kinase domain (LMTK3-KD). Characterisation of these interactions revealed that LMTK3

Indexed as

Breast NeoplasmsIntrinsically Disordered ProteinsProtein Serine-Threonine KinasesAmino Acid SequenceAnimalsCell Line, TumorCell ProliferationFemaleHumansMembrane ProteinsMicePhenotypePhosphorylationProtein BindingProtein DomainsIntrinsically Disordered ProteinsLMTK3 protein, humanMembrane ProteinsProtein Serine-Threonine Kinasesbreast cancerintrinsically disordered regionkinase regulationLMTK3phosphorylation

Identifiers

PMID42645201
PMCPMC13510533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.