Evidence map›Paper›PMID 42645186›Full record

ArticleCells2026

Mechanical Loading Prevents Bone Growth Impairment in TNF-Overexpressing Mice with Chronic Inflammation.

Tim R J Aeppli, Lucas Z Zhang, Elena M Gutierrez-Farewik, Eva Pontén, Farasat Zaman, Lars Sävendahl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tim R J AeppliDivision of Pediatric Endocrinology, Department of Women's and Children's Health, Karolinska Institutet, 171 77 Stockholm, Sweden.
Lucas Z ZhangDivision of Pediatric Endocrinology, Department of Women's and Children's Health, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0009-0009-9208-4398
Elena M Gutierrez-FarewikKTH MoveAbility, Department of Engineering Mechanics, KTH Royal Institute of Technology, 114 28 Stockholm, Sweden.ORCID 0000-0001-5417-5939
Eva PonténDepartment of Pediatric Orthopedic Surgery, Karolinska University Hospital, 171 76 Stockholm, Sweden.ORCID 0000-0001-5228-1914
Farasat ZamanDivision of Pediatric Endocrinology, Department of Women's and Children's Health, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-1832-1051
Lars SävendahlDivision of Pediatric Endocrinology, Department of Women's and Children's Health, Karolinska Institutet, 171 77 Stockholm, Sweden.

Funding

Åke Wibergs StiftelseChina Scholarship CouncilESPE (European Society for Pediatric Endocrinology) Research Fellowship, sponsored by Novo Nordisk A/SKarolinska Institutetmärta och gunnar v philipson foundationregion stockholm (alf)sällskåpet barnavardSvenska Frimurare OrdenSwedish Research Council 2018-00750, 2020-02025, 2024-03265Swiss National Science Foundation P2ZHP3_191254
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bone DevelopmentInflammationStress, MechanicalTumor Necrosis Factor-alphaAnimalsChronic DiseaseFemaleFemurGrowth PlateHumansMiceMice, Inbred C57BLMice, TransgenicRatsWeight-BearingTumor Necrosis Factor-alphabone growthcytokinesgrowth plateinflammationmechanical loadingtumor necrosis factor (TNF)

Identifiers

PMID42645186
PMCPMC13511311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.