Role of Astrocytes in Central Respiratory Control.

Yasumasa Okada, Isato Fukushi, Shigefumi Yokota, Kotaro Takeda, Akira Umeda, Mieczyslaw Pokorski, Hiroshi Onimaru

Abstract readReview

In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yasumasa OkadaClinical Research Center, Murayama Medical Center, 2-37-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan.ORCID 0000-0003-4774-8684

Isato FukushiClinical Research Center, Murayama Medical Center, 2-37-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan.ORCID 0000-0001-5007-3978

Shigefumi YokotaDepartment of Anatomy, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.ORCID 0000-0002-2823-7873

Kotaro TakedaClinical Research Center, Murayama Medical Center, 2-37-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan.ORCID 0000-0002-0446-4043

Akira UmedaDepartment of Respiratory Medicine, International University of Health and Welfare Shioya Hospital, Yaita 329-2145, Japan.ORCID 0000-0003-3115-9842

Mieczyslaw PokorskiInstitute of Health Sciences, University of Opole, 45-040 Opole, Poland.ORCID 0000-0002-8710-9775

Hiroshi OnimaruDepartment of Physiology, Showa Medical University School of Medicine, Tokyo 142-8666, Japan.

Funding

Japan Society for the Promotion of Science KAKENHI 24K14597

6 · The paper itself

Abstract

Astrocytes, once regarded primarily as structural and metabolic support cells, are now increasingly recognized as active participants in neural information processing. Within respiratory control networks, astrocytes are widely distributed throughout the brainstem and spinal cord, where they engage in bidirectional communication with neurons to regulate breathing. This review summarizes current knowledge regarding the roles of astrocytes in respiratory rhythm and pattern generation, central respiratory chemoreception, hypoxic ventilatory responses, respiratory plasticity, and respiratory pathophysiology. Recent advancements in calcium imaging, optogenetics, and pharmacology have revealed that astrocytes modulate respiratory network activity through intracellular Ca

Indexed as

AstrocytesRespirationAnimalsHumansastrocytegliahypercapnic ventilatory responsehypoxic ventilatory responseneurogliarespiratory controlrespiratory plasticityrespiratory rhythm generation

Identifiers

PMID42645175

DOI10.3390/cells15161447

PMCPMC13511040

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.