Evidence map›Paper›PMID 42645171›Full record

ArticleCells2026

Inflammasome Inhibitor MCC950 Attenuates Methamphetamine-Induced Hippocampal Neurotoxicity and Aberrant Neurogenesis in a Sex-Dependent Manner.

Mateusz Smolarz, Natalia Pondel, Gracjana Zając, Agata Kurczyk, Monika Pietrowska, Marta Gawin, Magdalena Dębiec, Andrzej Małecki, Marta Nowacka-Chmielewska, Michal Toborek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mateusz SmolarzInstitute of Physiotherapy and Health Sciences, Academy of Physical Education, 40-065 Katowice, Poland.ORCID 0000-0003-1124-0029
Natalia PondelInstitute of Physiotherapy and Health Sciences, Academy of Physical Education, 40-065 Katowice, Poland.ORCID 0000-0003-0684-1305
Gracjana ZającInstitute of Physiotherapy and Health Sciences, Academy of Physical Education, 40-065 Katowice, Poland.
Agata KurczykDepartment of Biostatistics and Bioinformatics, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.ORCID 0000-0002-4124-9385
Monika PietrowskaMaria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.
Marta GawinMaria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.
Magdalena DębiecInstitute of Physiotherapy and Health Sciences, Academy of Physical Education, 40-065 Katowice, Poland.
Andrzej MałeckiInstitute of Physiotherapy and Health Sciences, Academy of Physical Education, 40-065 Katowice, Poland.
Marta Nowacka-ChmielewskaInstitute of Physiotherapy and Health Sciences, Academy of Physical Education, 40-065 Katowice, Poland.ORCID 0000-0001-8668-8878
Michal ToborekInstitute of Physiotherapy and Health Sciences, Academy of Physical Education, 40-065 Katowice, Poland.ORCID 0000-0003-4475-2119

Funding

Akademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach AWF/NF/ZB1/2024National Science Centre 2019/35/B/NZ7/03155
6 · The paper itself

Abstract

Methamphetamine (METH) is a known proinflammatory agent; however, the impacts of inflammasomes on its neurotoxic effects are not fully understood. In the present study, we assessed the impact of prolonged METH administration on the hippocampal inflammasome profile in male and female mice and determined alterations of the inflammasome profile in response to METH. In addition to inflammasome activation, METH induced both systemic and hippocampal-specific inflammatory responses, leading to cognitive impairment, reduced hippocampal cell proliferation, and altered proteomic profiles. Importantly, the responses to METH exposure exhibited important sexual dimorphism. Treatment with inflammasome inhibitor MCC950 attenuated METH-induced inflammatory events; however, we also observed several off-target effects of this inhibitor affecting mouse anxiety-like behavior and cognitive function. Overall, our results indicate the preventive potential of MCC950 in METH-related neurotoxicity, while underscoring its limitations due to distinct sex-dependent differences in response to both METH and MCC950 and highlighting significant sexual dimorphism.

Indexed as

FuransHeterocyclic Compounds, 4 or More RingsHippocampusIndenesInflammasomesMethamphetamineNeurogenesisSulfonamidesSulfonesAnimalsFemaleMaleMiceMice, Inbred C57BLSex CharacteristicsFuransHeterocyclic Compounds, 4 or More RingsIndenesInflammasomesMethamphetamineN-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamideSulfonamidesSulfonesbehaviorcognitioninflammasomeMCC950methamphetamineneuroinflammation

Identifiers

PMID42645171
PMCPMC13511100

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.