Laser-Induced Graphene Electrodes for Wrist-Worn Impedance Plethysmography Measurements: A Feasibility Study.

Electrical bioimpedance (BioZ) has emerged as a promising technique for the non-invasive monitoring of physiological parameters, owing to its ability to map functional activity into electrical changes. Particularly, impedance plethysmography (IPG) is used to track blood volume changes associated with cardiac activity. However, developing flexible, low-cost devices with enough sensitivity to serve as high-precision for IPGs remains an open challenge. In this work, we introduce laser-induced graphene (LIG) electrodes as an attractive alternative for IPG measurements. The electrodes were fabricated by generating LIG on a polyimide substrate using a 405 nm laser diode and were subsequently characterized morphologically, structurally, and electrically to produce a wrist-worn cardiac impedance sensor (WCIS). The design of the WCIS is based on interdigitated electrodes to detect IPG variations at the radial artery, from which the heart rate is estimated. We show experimental results on IPG signal analysis and its validation against electrocardiogram (ECG) signals as the gold standard. As a result, a mean absolute error (MAE) of 1.7 bpm, a root mean square error (RMSE) of 2.1 bpm, and a limit of agreement of approximately ±6 bpm were obtained. These outcomes demonstrate the feasibility of the WCIS as a promising, low-cost alternative for continuous, non-invasive cardiovascular monitoring in portable devices, based on the IPG principle.