Exceptional-Point-Enhanced Chiral Spoof Localized Surface Plasmon Resonator for Sub-Microliter Glucose Microwave Biosensing.

Microwave resonance sensors are promising for dielectric characterization and biochemical detection. However, their sensing performance is constrained by the relatively long wavelength at microwave frequencies and the limited electromagnetic interaction with small-volume samples. In this paper, an exceptional-point (EP)-enhanced chiral spoof localized surface plasmon (SLSP) resonator is proposed for high sensitivity microwave biosensing with sub-microliter sample volumes. By rotating the chiral resonator relative to the microstrip feeding line, two EPs are obtained at α = 49° and α = 210°. The simulated results show that the EP states generate larger frequency splitting than the reference state under both dielectric-constant variation and detection-limit evaluation, confirming the squareroot response to weak perturbations. Experiments further validate the sensing performance using low-loss dielectric materials and high-loss glucose solutions. For dielectric samples with relative permittivities from 2 to 6.15, the frequency splitting increases from 0.287 GHz to 0.359 GHz. For glucose solutions, the frequency splitting decreases from 1.506 GHz to 1.372 GHz as the glucose amount increases from 2.78 nmol to 27.8 nmol. The proposed sensor requires only about 0.5 μL of sample volume and shows higher sensitivity than reported microwave glucose sensors. These results demonstrate that the EP-enhanced chiral SLSP resonator provides a compact and sensitive platform for trace-volume biochemical detection and integrated microwave biosensing.