Evidence map›Paper›PMID 42644963›Full record

ArticleGels (Basel, Switzerland)2026

Efficient Preparation of pH-Sensitive Core-Shell Drug-Loaded Hydrogel Microcapsules and Their Application in Ulcerative Colitis Treatment.

Qingqing Xue, Yingli Li, Qing Ao, Guowang Chang, Yang Ji, Shizhang Chen, Ze Wang, Zifan Wang, Zhiqiang Li, Lei Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qingqing XueKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Engineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Gansu Tech Innovation Center of Animal Cell, China-Malaysia National Joint Laboratory, Northwest Minzu University, Lanzhou 730030, China.
Yingli LiKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Engineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Gansu Tech Innovation Center of Animal Cell, China-Malaysia National Joint Laboratory, Northwest Minzu University, Lanzhou 730030, China.
Qing AoKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Engineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Gansu Tech Innovation Center of Animal Cell, China-Malaysia National Joint Laboratory, Northwest Minzu University, Lanzhou 730030, China.
Guowang ChangKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Engineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Gansu Tech Innovation Center of Animal Cell, China-Malaysia National Joint Laboratory, Northwest Minzu University, Lanzhou 730030, China.
Yang JiSchool of Life Sciences and Engineering, Northwest Minzu University, Lanzhou 730124, China.
Shizhang ChenSchool of Life Sciences and Engineering, Northwest Minzu University, Lanzhou 730124, China.
Ze WangKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Engineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Gansu Tech Innovation Center of Animal Cell, China-Malaysia National Joint Laboratory, Northwest Minzu University, Lanzhou 730030, China.
Zifan WangKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Engineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Gansu Tech Innovation Center of Animal Cell, China-Malaysia National Joint Laboratory, Northwest Minzu University, Lanzhou 730030, China.
Zhiqiang LiDepartment of Medical, Northwest Minzu University, Lanzhou 730030, China.
Lei ZhaoKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Engineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Gansu Tech Innovation Center of Animal Cell, China-Malaysia National Joint Laboratory, Northwest Minzu University, Lanzhou 730030, China.ORCID 0000-0002-2262-6480

Funding

Discipline Construction Fund of Northwest Minzu University 31920250002Gansu Province Major Special Projects Program 26ZDFA003National Natural Science Foundation of China 22104046Open Fund Project of Northwest Minzu University 31920260052
6 · The paper itself

Abstract

Conventional microsphere drug carriers for ulcerative colitis (UC) face challenges such as limited residence time, variable drug release, and an increased risk of systemic exposure and side effects. In this study, pH-sensitive, core-shell hydrogel microcapsules were designed and fabricated using a BUCHI B-390 microsphere preparation device via electrostatic interactions and hydrogen bonds. Olsalazine sodium was encapsulated in the microcapsules, allowing for pH-responsive drug release in colon tissue for UC treatment in mice. XRD studies demonstrated the amorphous state of the drug in the formulation. The preparation of SCO microcapsules was optimized based on the drug encapsulation efficiency and the drug loading capacity, with the S

Indexed as

carboxymethyl chitosancore–shell microcapsulesolsalazine sodiumpH sensitivitysodium alginateulcerative colitis

Identifiers

PMID42644963
PMCPMC13512429

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.