Evidence map›Paper›PMID 42644961›Full record

ArticleGels (Basel, Switzerland)2026

Lentinan-Based Multifunctional Composite Hydrogel for Wound Healing.

Niu Liu, Wengui Xu, Xinmiao He, Jinwang Zou, Jinhao Pan, Chenyi Feng, Yao Wu, Changchun Li, Hairong Xiong, Zongbao Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Niu LiuHubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China.
Wengui XuHubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China.
Xinmiao HeHubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China.
Jinwang ZouHubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China.
Jinhao PanHubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China.
Chenyi FengHubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China.
Yao WuHubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China.
Changchun LiHubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China.ORCID 0000-0002-4699-8609
Hairong XiongHubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China.
Zongbao ZhouHubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China.ORCID 0000-0002-5944-2693

Funding

Central Guidance for Local Science and Technology Development Fund Project 2025CSA127Hubei Provincial Natural Science Foundation Xiaogan Innovation Development Joint Fund 2026AFC0674Xiaogan Natural Science Program Project XGKJ2024010017Youth Talent Program of the Scientific Research Plan of Hubei Provincial Department of Education Q20242704
6 · The paper itself

Abstract

Conventional wound dressings suffer from unbalanced tissue adhesion, skin-mismatched mechanical properties, and insufficient long-term bioactivity. Herein, a dual physically cross-linked multifunctional tissue adhesive lentinan-polyvinyl alcohol (PVA)-tannic acid membrane (LPTM) was fabricated via a freeze-thaw-assisted immersion strategy. The optimized LPTM-3 hydrogel patch, with a stable network formed by PVA crystalline cross-linking and hydrogen bond cross-linking, achieved a balanced tensile strength of 16.1 MPa and an elongation at break of 149.3%, robust yet non-damaging porcine skin adhesion of 163.17 kPa, antibacterial activity, and good biocompatibility with a hemolysis rate below 2.24%. Notably, LPTM-3 promoted fibroblast migration and modulated inflammatory cytokine expression in vitro, and achieved 99.06% full-thickness wound closure in rats on day 14, matching a commercial dressing. This work provides a promising candidate for clinical wound repair and a facile design strategy for polysaccharide-based bioadhesive materials.

Indexed as

lentinantannic acidtissue-adhesive hydrogelwound dressing

Identifiers

PMID42644961
PMCPMC13512174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.