Evidence map›Paper›PMID 42644898›Full record

ArticleEpidemiologia (Basel, Switzerland)2026

The Epidemiological Scenario of Human Leptospirosis in Brazil from 2015 to 2024.

George S C Fernandes, Bruna O P Azevedo, Deborah K Damiano, Mikael V R Lima, Pablo P Macena, Aline F Teixeira, Giovana C Barazzone, Ana L T O Nascimento, Alexandre P Y Lopes

Abstract read
In one paragraph

Article in Epidemiologia (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

George S C FernandesLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, 1500 Av. Vital Brasil, São Paulo 05503-900, SP, Brazil.ORCID 0009-0009-1956-9997
Bruna O P AzevedoLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, 1500 Av. Vital Brasil, São Paulo 05503-900, SP, Brazil.
Deborah K DamianoLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, 1500 Av. Vital Brasil, São Paulo 05503-900, SP, Brazil.ORCID 0000-0001-5514-8246
Mikael V R LimaLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, 1500 Av. Vital Brasil, São Paulo 05503-900, SP, Brazil.ORCID 0000-0003-1084-615X
Pablo P MacenaLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, 1500 Av. Vital Brasil, São Paulo 05503-900, SP, Brazil.ORCID 0009-0008-9562-2078
Aline F TeixeiraLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, 1500 Av. Vital Brasil, São Paulo 05503-900, SP, Brazil.ORCID 0000-0002-1171-8312
Giovana C BarazzoneLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, 1500 Av. Vital Brasil, São Paulo 05503-900, SP, Brazil.ORCID 0000-0001-8601-8452
Ana L T O NascimentoLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, 1500 Av. Vital Brasil, São Paulo 05503-900, SP, Brazil.ORCID 0000-0003-4851-0870
Alexandre P Y LopesLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, 1500 Av. Vital Brasil, São Paulo 05503-900, SP, Brazil.ORCID 0000-0003-0204-3875

Funding

Fundação Butantan (Butantan Foundation)
6 · The paper itself

Abstract

backgroundLeptospirosis is a neglected tropical disease with substantial public health impact in Brazil, closely associated with socio-environmental vulnerabilities and climatic extremes. This study analyzed the epidemiological profile and spatiotemporal distribution of leptospirosis incidence and lethality rates in Brazil from 2015 to 2024.

methodsAn ecological time-series study was conducted using secondary data from the Notifiable Diseases Information System (SINAN). Variables included geographic region, probable infection environment, and occupational and educational level (ISCED-2011).

resultsA total of 31,397 cases were notified, with an annual average of 3140 cases. The South and North regions exhibited the highest incidence rates, while the Northeast and Southeast presented lethality rates above the national average (9.20%). A marked reduction in notifications occurred during the COVID-19 pandemic. Infections occurred predominantly in the domiciliary environment (64%). Rural workers (27.45%) and civil construction workers (18.63%) were the most affected occupational groups, with a higher incidence rate among illiterate and low-education populations.

conclusionsThe dynamics of leptospirosis in Brazil are complex and multifactorial, influenced by climatic variations and driven by deficits in basic sanitation and education level. Mitigating the disease burden requires sustained, region-specific public health strategies, targeted infrastructure improvements, and enhanced epidemiological surveillance to address underreporting.

Indexed as

Brazilhuman leptospirosiszoonosis

Identifiers

PMID42644898
PMCPMC13512638

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.