Evidence map›Paper›PMID 42644878›Full record

ArticleAdvances in respiratory medicine2026

Left Ventricular Diastolic Dysfunction in Patients with Interstitial Lung Disease-A Potential Treatable Trait.

Ophir Freund, Uriel Katsoff, Tzlil Hershko, Ayala Ron, Shir Frydman, Doron Cohn-Schwartz, Aviv Kupershmidt, Neta Mano, Ariel Melloul, Eyal Kleinhendler and 2 more

Abstract read
In one paragraph

Article in Advances in respiratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ophir FreundInstitute of Pulmonary Medicine, Sourasky Medical Center, Tel Aviv 6423906, Israel.ORCID 0000-0002-7272-5284
Uriel KatsoffCenter of Excellence for Interstitial Lung Diseases, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Tzlil HershkoInstitute of Pulmonary Medicine, Sourasky Medical Center, Tel Aviv 6423906, Israel.ORCID 0009-0008-0468-5162
Ayala RonInstitute of Pulmonary Medicine, Sourasky Medical Center, Tel Aviv 6423906, Israel.
Shir FrydmanGray Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0002-8882-9109
Doron Cohn-SchwartzInstitute of Pulmonary Medicine, Sourasky Medical Center, Tel Aviv 6423906, Israel.
Aviv KupershmidtInstitute of Pulmonary Medicine, Sourasky Medical Center, Tel Aviv 6423906, Israel.
Neta ManoInstitute of Pulmonary Medicine, Sourasky Medical Center, Tel Aviv 6423906, Israel.
Ariel MelloulInstitute of Pulmonary Medicine, Sourasky Medical Center, Tel Aviv 6423906, Israel.
Eyal KleinhendlerInstitute of Pulmonary Medicine, Sourasky Medical Center, Tel Aviv 6423906, Israel.ORCID 0000-0001-9720-9246
Amir Bar-ShaiInstitute of Pulmonary Medicine, Sourasky Medical Center, Tel Aviv 6423906, Israel.
Avraham UntermanInstitute of Pulmonary Medicine, Sourasky Medical Center, Tel Aviv 6423906, Israel.ORCID 0000-0003-0965-3326

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular comorbidities complicate interstitial lung disease (ILD) and represent potential therapeutic targets, yet the prevalence and clinical impact of left ventricular diastolic dysfunction (LVDD) remain poorly characterized. We aimed to evaluate LVDD as a potential treatable trait within a prospective cohort. Using data from an ILD registry (January 2021-October 2024), we defined clinically relevant LVDD as echocardiographic grade 2 or 3 diastolic dysfunction. Out of 276 patients (median age 69, 44% female), 14% had LVDD, which was almost entirely in patients with fibrosis (97%,

Indexed as

Lung Diseases, InterstitialVentricular Dysfunction, LeftAgedEchocardiographyFemaleHumansMaleMiddle AgedPrognosisProspective StudiesRegistriesheart failureleft ventricle dysfunctionlung fibrosisprognosistreatable traits

Identifiers

PMID42644878
PMCPMC13510215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.