ArticleMicrobiology spectrum2026
Implications of edge cases for antimicrobial susceptibility predictions for rifampin, delamanid, and pretomanid with the WHO
Noud Hermans, Jody Phelan, Rita Sorrentino, Fenja Boysen, Norelle L Sherry, Paolo Miotto, Daniela Maria Cirillo, Leonid Chindelevitch, Timothy C Rodwell, Ivan Barilar and 15 more
Abstract read
In one paragraphArticle in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
25 authors.
Noud HermansDiagnostics Team, Division of Tuberculosis Elimination & Health Systems Innovations, KNCV Tuberculosis Foundation, The Hague, The Netherlands.ORCID 0009-0008-9037-9910 Jody PhelanDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0001-8323-7019 Rita SorrentinoEmerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0001-9674-0959 Fenja BoysenNational and WHO-Supranational Reference Laboratory for Mycobacteria, Leibniz Lung Center, Borstel, Germany.ORCID 0009-0009-6866-1482 Norelle L SherryMicrobiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, University of Melbourne at the Peter Doherty Institute for Infection & Immunity, Melbourne, Victoria, Australia.ORCID 0000-0002-7789-8360 Paolo MiottoEmerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0003-4610-2427 Daniela Maria CirilloEmerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0001-6415-1535 Leonid ChindelevitchMRC Center for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom.ORCID 0000-0002-6619-6013 Timothy C RodwellDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, San Diego, California, USA.ORCID 0000-0003-2779-3197 Stefan NiemannMolecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.ORCID 0000-0002-6604-0684 Sönke AndresNational and WHO-Supranational Reference Laboratory for Mycobacteria, Leibniz Lung Center, Borstel, Germany.ORCID 0009-0009-6063-3487 Alexander MischnikNational and WHO-Supranational Reference Laboratory for Mycobacteria, Leibniz Lung Center, Borstel, Germany.ORCID 0000-0003-2326-4132 Kristy HoranMicrobiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, University of Melbourne at the Peter Doherty Institute for Infection & Immunity, Melbourne, Victoria, Australia.ORCID 0009-0003-2636-7820 Katherine BondMycobacterium Reference Laboratory, Victorian Infectious Diseases Laboratory, at The Peter Doherty Institute for Infection & Immunity, Melbourne, Victoria, Australia.ORCID 0000-0002-4473-9232 Maria GlobanMycobacterium Reference Laboratory, Victorian Infectious Diseases Laboratory, at The Peter Doherty Institute for Infection & Immunity, Melbourne, Victoria, Australia.ORCID 0000-0002-3400-2843 Mor RubinsteinNational Public Health Laboratory, Public Health Directorate, Ministry of Health, Tel Aviv, Israel.ORCID 0000-0002-0509-9164 Yelena LosevNational Public Health Laboratory, Public Health Directorate, Ministry of Health, Tel Aviv, Israel.ORCID 0009-0004-6559-4142 Taane G ClarkDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0001-8985-9265 Satoshi MitaraiDepartment of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Tokyo, Japan.ORCID 0000-0002-2288-077X Andrii SlyzkyiDiagnostics Team, Division of Tuberculosis Elimination & Health Systems Innovations, KNCV Tuberculosis Foundation, The Hague, The Netherlands.ORCID 0000-0002-6757-9374 Claudio U KöserEmerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-0232-846X Kristin KremerDiagnostics Team, Division of Tuberculosis Elimination & Health Systems Innovations, KNCV Tuberculosis Foundation, The Hague, The Netherlands.ORCID 0009-0004-1729-5463 Richard AnthonyDepartment Bacterial Surveillance and Response, Center for Infectious Disease Control, Diagnostics and Laboratory Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.ORCID 0000-0002-0550-5273 Funding
Automated Sequencing for Culture-free Diagnosis of Drug Resistant TBR01AI176401 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Rebecca Elizabeth Colman, Timothy Charles Rodwell · 2023 to 2026
$2.9MDutch Postcode Lottery, and the Dutch Ministry of Health, Welfare and Sports Dream Fund project "No more pandemics"EPSRC EP/Y018842/1European Centre for Disease Prevention and Control ECDC/GRANT/2022/010MRC Centre for Global Infectious Disease Analysis MR/R015600/1National Health Research Council Australia NHMRC, GNT2033803NIH NIAID R01AI176401StopTB Partnership STBP/NT/GSA/2024-02UKRI MRC MR/X005895/1
6 · The paper itselfAbstract
The WHO mutation catalog is the reference for genotypic antimicrobial susceptibility predictions (ASPs) for
Indexed as
Antitubercular AgentsMycobacterium tuberculosisNitroimidazolesOxazolesRifampinBacterial ProteinsDNA-Directed RNA PolymerasesDrug Resistance, BacterialGenotypeHumansMicrobial Sensitivity TestsMutationAntitubercular AgentsBacterial ProteinsDNA-Directed RNA PolymerasesNitroimidazolesOPC-67683OxazolespretomanidRifampinrpoB protein, Mycobacterium tuberculosisdelamanidMycobacterium tuberculosispretomanidrifampinwhole-genome sequencingWHO mutation catalog
Identifiers
PMID42644623
PMCPMC13689116
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