Evidence map›Paper›PMID 42644590›Full record

ArticleThoracic cancer2026

Intraoperative Contrast-Enhanced Ultrasonography (Io-CEUS) to Detect Missed Lung Nodules During Robot-Assisted Thoracoscopic Surgery.

Alfonso Fiorelli, Antonio Marella, Marco Aiello, Valentina Brancato, Marco Salvatore, Daniela Comunale, Francesco Ferrigno, Gaetana Messina

Abstract readCase Reports
In one paragraph

Article in Thoracic cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alfonso FiorelliThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0000-0002-0628-613X
Antonio MarellaThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0009-0005-3499-196X
Marco AielloIRCCS Synlab SDN, Naples, Italy.ORCID https://orcid.org/0000-0002-3676-0664
Valentina BrancatoIRCCS Synlab SDN, Naples, Italy.ORCID https://orcid.org/0000-0002-6232-7645
Marco SalvatoreIRCCS Synlab SDN, Naples, Italy.ORCID https://orcid.org/0000-0001-9734-7702
Daniela ComunaleOncology Unit, Salerno Hospital, Salerno, Italy.
Francesco FerrignoASL SA, Salerno, Italy.
Gaetana MessinaThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0000-0001-5129-7201

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we reported the use of Intraoperative-Contrast Enhanced Ultrasonography (Io-CEUS) during Robotic Assisted Thoracic Surgery (RATS) for identification of malignant lung nodule that was missed during previous operation. Pre-operative CT scan with 3D reconstruction defined the prompt position of the target lesion within S8 segment of right lower lobe and the anatomic landmarks as the distance from interlobar fissure and diaphragm. The lesion was then successfully detected by Io-CEUS. The different arterial enhancement observed during wash-in (hyperenhancement) and wash-out (hypo-enhancement) phases helped to differentiate the nodule from lung parenchyma. The lesion was resected by mechanical stapler and frozen section analysis diagnosed metastasis from colon carcinoma. Post-operative course was unremarkable; patient was discharged on post-operative day 3.

Indexed as

Contrast MediaLung NeoplasmsRobotic Surgical ProceduresThoracoscopyHumansMaleUltrasonographyContrast MediaCEUSintra‐operative ultrasoundlung cancerrobotic surgery

Identifiers

PMID42644590
PMCPMC13509023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.