SynthesisOral health & preventive dentistry2026
Effects of Hyaluronic Acid in the Surgical Treatment of Periodontitis: A Systematic Review.
Synthesis in Oral health & preventive dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHyaluronic acid (HA) is a naturally occurring polymer synthesised endogenously in the human body, with distinctive physicochemical and biological properties such as excellent biocompatibility and biodegradability. These characteristics have led to extensive research into its therapeutic potential, particularly in the management of inflammatory diseases. This systematic review aimed to evaluate the effects of HA on clinical outcomes in the surgical treatment of periodontitis. METHODS AND MATERIALS: This review was registered with PROSPERO (CRD42024493296) and conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. A systematic search was performed in PubMed, Cochrane, and Scopus up to September 2025. Randomised controlled trials assessing HA clinical outcomes in the surgical treatment of periodontitis were included.
resultsNine RCTs including a total of 343 patients were analysed. Sample sizes ranged from 14 to 60 participants, with follow-up periods between 3 and 24 months. The adjunctive use of HA in the surgical treatment of periodontitis led to consistent improvements, with probing depth (PD) reductions of 2.0-3.5 mm and CAL gains of 2.0-3.8 mm after 6-12 months. Radiographic evaluations also showed greater bone fill in intrabony defects.
conclusionWithin the limits of available randomised controlled trials, HA shows potential as an adjunct in the surgical management of periodontitis. Although reported improvements in clinical parameters are encouraging, evidence remains heterogeneous and requires confirmation through standardised, long-term studies.
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