Evidence map›Paper›PMID 42644421›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Elucidating the neuropathological and molecular heterogeneity of amyloid beta and tau in Alzheimer's disease through machine learning and transcriptomic integration.

Kanhao Zhao, Hua Xie, Tovia Jacobs, Naomi L Gaggi, Juan Fortea, Nancy B Carlisle, Gregory A Fonzo, Kilian M Pohl, Ricardo S Osorio, Yu Zhang and 1 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kanhao ZhaoDepartment of Bioengineering, Lehigh University, Bethlehem, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-2955-0917
Hua XieCenter for Neuroscience Research, Children's National Hospital, Washington, District of Columbia, USA.
Tovia JacobsPenn State College of Medicine, Hershey, Pennsylvania, USA.
Naomi L GaggiDepartment of Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.
Juan ForteaSant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau, Barcelona, Spain.
Nancy B CarlisleDepartment of Psychology, Lehigh University, Bethlehem, Pennsylvania, USA.
Gregory A FonzoCenter for Psychedelic Research and Therapy, Department of Psychiatry and Behavioral Sciences, Dell Medical School, The University of Texas at Austin, Austin, Texas, USA.
Kilian M PohlDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Ricardo S OsorioDepartment of Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.
Yu ZhangDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.ORCID https://orcid.org/0000-0003-4087-6544
ADNI Study Group and the PREVENT‐AD Research Group

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4M
DS-ARC: A Remote Digital Cognitive Assessment for Down Syndrome-Associated Alzheimer's DiseaseR01AG081394 · NIA · WASHINGTON UNIVERSITY · PI Jason J Hassenstab · 2023 to 2026
$6.0M
The Role of Inflammation and NGF Dysfunction in the Evolution of Alzheimer Disease Pathology in Down Syndrome-RevisionRF1AG056850 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSCIGLIO, JORGE A, CUELLO, A CLAUDIO · 2018 to 2020
$5.9M
Clinical trials to prevent Alzheimer's Disease in Down SyndromeR61AG066543 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RAFII, MICHAEL S · 2019 to 2020
$5.6M
Tau pathology in Down syndrome and Alzheimer'sRF1AG061566 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, MARGITTAI, MARTIN · 2019 to 2019
$3.4M
Multidisciplinary Research Training in Sleep ScienceT32HL160511 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI INDU A AYAPPA, ANDREW W VARGA · 2023 to 2026
$1.5M
Assess Neural Circuits and Subtypes Underlying Dimensions of Neuropsychiatric Symptoms in Alzheimer's DiseaseR21AG080425 · NIA · LEHIGH UNIVERSITY · PI ZHANG, YU · 2023 to 2024
$426k
Biological Correlates of Alzheimer in Down Syndrome.R21AG056974 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER · 2017 to 2018
$414k
Alzheimer's Association AARG-22-972541NHLBI NIH HHS T32 HL160511NIA NIH HHS P30 AG066512NIA NIH HHS R01 AG081394NIA NIH HHS R21 AG056974NIA NIH HHS R21 AG080425NIA NIH HHS R21AG080425NIA NIH HHS R61 AG066543NIA NIH HHS RF1 AG056850NIA NIH HHS RF1 AG061566NIA NIH HHS U01 AG024904Stanford Knight Initiative for Brain Resilience and the Rosenkranz Foundation grant RAR1-03
6 · The paper itself

Abstract

introductionFunctional brain network alterations associated with Alzheimer's disease (AD) pathology, including amyloid beta (Aβ) and phosphorylated tau (p-tau), are difficult to interpret due to overlapping aging-associated and non-amyloid biological processes.

methodsWe analyzed resting-state functional magnetic resonance imaging (fMRI) from 289 older adults classified as Aβ-positive (A

resultsA

conclusionThese findings suggest that contrastive graph learning may help separate amyloid-associated functional network variation from broader background biological variability, providing insight into the heterogeneity of AD-related biomarkers and cognitive dysfunction.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrainMachine Learningtau ProteinsTranscriptomeAgedAged, 80 and overAgingBiomarkersFemaleHumansMagnetic Resonance ImagingMaleAmyloid beta-PeptidesBiomarkerstau ProteinsagingAlzheimer's diseasecontrastive machine learningfunctional connectivityfunctional magnetic resonance imaging

Identifiers

PMID42644421
PMCPMC13508589

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.