Evidence map›Paper›PMID 42644412›Full record

ReviewImmunological reviews2026

Some Exposure for Influenza Hemagglutinin Interface Antibodies.

Kevin R McCarthy

Abstract readReview
In one paragraph

Review in Immunological reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Kevin R McCarthyCenter for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1016-6015

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza viruses are a constant threat to human health. Current vaccines often confer low to moderate protection against infection with seasonal viruses and little-to-no protection against pandemic viruses. Improved vaccines are needed. These vaccines will need to reliably elicit antibodies to conserved sites that are broadly protective. One strategy to do so is to design immunogens that present epitopes that are targeted by antibodies that are genetically similar, that humans have the genetic capacity to produce, and that are likely present in human naive B cell repertoires. Among the more recently described epitopes for broadly binding, protective antibodies are those on surfaces at protein-protein interfaces. This review will focus on describing many of these sites and the genetic features of antibodies that engage them. Interface epitopes are immunogenic, and antibodies to these sites are likely present in human repertoires following influenza infection or vaccination.

Indexed as

Antibodies, ViralHemagglutinin Glycoproteins, Influenza VirusInfluenza, HumanInfluenza VaccinesOrthomyxoviridaeAnimalsEpitopesHumansAntibodies, ViralEpitopesHemagglutinin Glycoproteins, Influenza VirusInfluenza Vaccines

Identifiers

PMID42644412
PMCPMC13508182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.