Evidence map›Paper›PMID 42644382›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

The microdialysis-derived lactate-pyruvate gradient indicates anaerobic activity after brain injury.

Michael S Baker, Joshua M Heihre, Tomasz Kuliński, Claudia A Smith, Berfin Barlas, Chisomo Zimphango, Ivan Timofeev, Koby Baranes, Keri L H Carpenter, Mark Kotter and 4 more

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Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michael S BakerDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0009-0006-3078-3001
Joshua M HeihreDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0009-0008-6151-6410
Tomasz KulińskiSection of Neurosurgery, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.ORCID 0000-0002-7517-8861
Claudia A SmithDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0000-0003-3643-6191
Berfin BarlasDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Chisomo ZimphangoDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Ivan TimofeevDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1168-0393
Koby BaranesDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6887-3241
Keri L H CarpenterDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Mark KotterDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Mathew R GuilfoyleDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Elham RostamiSection of Neurosurgery, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.
Peter J HutchinsonDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Adel HelmyDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0000-0002-0531-0556

Funding

Wellcome Trust
6 · The paper itself

Abstract

Cerebral microdialysis (CMD) after traumatic brain injury (TBI) has focused on lactate/pyruvate ratio (LPR), overlooking lactate-pyruvate gradient (LPG, the linear regression slope within a time segment of CMD datapoints) as a proxy for anaerobic activity. We retrospectively applied changepoint detection to the linear lactate-pyruvate relationship (L =

Indexed as

Cerebral metabolismchangepoint detectionmitochondrial dysfunctionneurocritical careneuromonitoring

Identifiers

PMID42644382
PMCPMC13558473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.