In one paragraphArticle in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01934725 (Searching for Explanations for Cryptogenic Stroke in the Young), which is not on this map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO)
TypeobservationalSponsorSECRETO Study ConsortiumRan2013 to 2031Enrolled1,200ConditionsBrain Infarction, Ischemic Stroke, Thrombosis, Foramen Ovale, Patent
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
48 authors.
Julija ValančienėDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Finland (J.V.).ORCID 0009-0000-3109-9195 Pauli YlikotilaDepartment of Neurology, Turku University Hospital and University of Turku, Finland (P.Y.).ORCID 0009-0002-4126-9666 Riikka LautamäkiHeart Center, Turku University Hospital, Finland (R. Lautamäki).
Marialuisa ZeddeNeurology Unit, Stroke Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS Reggio Emilia, Italy.ORCID 0000-0001-7530-818X Teresa GrimaldiCardiology Unit (T.G.), Azienda Unità Sanitaria Locale-IRCCS Reggio Emilia, Italy.
Tomi SarkanenDepartment of Neurology, Tampere University Hospital, Wellbeing Services County of Pirkanmaa and Faculty of Medicine and Health Technology, Tampere University, Finland (T. Sarkanen).ORCID 0000-0001-8815-2807 Essi RyödiHeart Hospital, Tampere University Hospital, Finland (E.R.).
Dalius JatužisDepartment of Neurology and Neurosurgery (J.V., D.J., K.R.), Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, Lithuania.ORCID 0000-0001-6159-4795 Kristina RyliškienėDepartment of Neurology and Neurosurgery (J.V., D.J., K.R.), Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, Lithuania.ORCID 0000-0001-9596-1733 Diana ZakarkaitėDepartment of Cardiac and Vascular Diseases (D.Z.), Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, Lithuania.ORCID 0000-0003-3299-7135 Raila BuschDepartment of Internal Medicine B (Cardiology) (R.B.), University Medicine Greifswald, Germany.ORCID 0009-0006-4676-3363 Lauri TulkkiDepartment of Neurology (L.T., N.M.-M., J. Putaala), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0003-2823-8574 Jani PirinenDepartment of Cardiology, Heart and Lung Center (J. Pirinen, S. Suihko, H.T., M.L., J.S.), Helsinki University Hospital and University of Helsinki, Finland.
Nicolas Martinez-MajanderDepartment of Neurology (L.T., N.M.-M., J. Putaala), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0001-8489-7051 Radim LicenikAcute Stroke Centre, North West Anglia Foundation NHS Trust, Peterborough, United Kingdom (R. Licenik).ORCID 0000-0002-9145-4598 Phillip FerdinandNeurosciences (P.F.), University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, United Kingdom.
Cheryl OxleyCardiac Physiology Services (C.O.), University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, United Kingdom.
Tuukka A HelinDepartment of Clinical Chemistry, HUS Diagnostic Center (T.A.H., L.J.-K.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-5273-8088 Lotta Joutsi-KorhonenDepartment of Clinical Chemistry, HUS Diagnostic Center (T.A.H., L.J.-K.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-7355-2354 Tímea SzántóUnit of Coagulation Disorders, Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center and University of Helsinki, Finland (T. Szántó).ORCID 0000-0001-7006-6564 Carlo Mario LombardiCardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (C.M.L.).ORCID 0000-0002-7120-5877 Georgios TsivgoulisSecond Department of Neurology, National & Kapodistrian University of Athens, Attikon University Hospital, Greece (G.T.).ORCID 0000-0002-0640-3797 Satu SuihkoDepartment of Cardiology, Heart and Lung Center (J. Pirinen, S. Suihko, H.T., M.L., J.S.), Helsinki University Hospital and University of Helsinki, Finland.
Heli TolppanenDepartment of Cardiology, Heart and Lung Center (J. Pirinen, S. Suihko, H.T., M.L., J.S.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-3364-8554 Ana Catarina FonsecaFaculty of Medicine, Hospital Santa Maria, University of Lisbon, Portugal (A.C.F.).ORCID 0000-0001-6913-5526 Patricia Martínez-SánchezDepartment of Neurology, Torrecardenas University Hospital, University of Almería, Spain (P.M.-S., L.A.-P.).ORCID 0000-0003-1945-4435 Laura Amaya-PascasioDepartment of Neurology, Torrecardenas University Hospital, University of Almería, Spain (P.M.-S., L.A.-P.).ORCID 0000-0003-1162-4209 Sofie AbelsDepartment of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands (S.A.).ORCID 0009-0009-4850-9918 Frank-Erik de LeeuwDepartment of Neurology, Radboud Institute of Medical Innovation, Donders Institute for Brain, Cognition and Behavior, Nijmegen, the Netherlands (F.-E.d.L.).ORCID 0000-0003-2221-3026 Nilufer YesilotDepartment of Neurology (N.Y.), Istanbul University, Istanbul Faculty of Medicine, Turkey.ORCID 0000-0002-9655-9487 Mine SezginDepartment of Cardiology (M.S.), Istanbul University, Istanbul Faculty of Medicine, Turkey.ORCID 0000-0001-6525-0658 Ulrike Waje-AndreassenDepartment of Neurology (U.W.-A.), Haukeland University Hospital, Bergen, Norway.ORCID 0000-0003-3240-6040 Petra RedforsDepartment of Neurology, Sahlgrenska University Hospital and Department of Clinical Neuroscience, Institute of Neuroscience and Physiology (P.R.), Sahlgrenska Academy at University of Gothenburg, Sweden.ORCID 0000-0001-5956-4255 Odd Bech-HanssenDepartment of Clinical Physiology, Institute of Medicine (O.B.-H.), Sahlgrenska Academy at University of Gothenburg, Sweden.ORCID 0000-0002-9572-9819 Juha HuhtakangasDepartment of Neurology, Oulu University Hospital and University of Oulu, Finland (J.H.).ORCID 0000-0001-7143-519X Pekka JäkäläNeurocenter Neurology, Kuopio University Hospital and University of Eastern Finland, Finland (P.J.).ORCID 0000-0002-8410-6915 Hugo Ten CateDepartment of Internal Medicine and Thrombosis Expertise Center, Maastricht University Medical Center and CARIM School for Cardiovascular Diseases, the Netherlands (H.t.C.).ORCID 0000-0001-7796-4463 Eva GerdtsDepartment of Internal Medicine and Thrombosis Expertise Center, Maastricht University Medical Center and CARIM School for Cardiovascular Diseases, the Netherlands (H.t.C.).ORCID 0000-0003-4109-2311 Mika LehtoDepartment of Cardiology, Heart and Lung Center (J. Pirinen, S. Suihko, H.T., M.L., J.S.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-8691-5142 Juha SinisaloDepartment of Cardiology, Heart and Lung Center (J. Pirinen, S. Suihko, H.T., M.L., J.S.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-0169-5137 Jukka PutaalaDepartment of Neurology (L.T., N.M.-M., J. Putaala), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-6630-6104 SECRETO Study Group Investigators
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundIn young adults, the risk factors (RFs) for cryptogenic ischemic stroke (CIS) remain unclear. We aimed to investigate the association between recent mechanical venous thrombosis RFs (VTRFs) and young-onset CIS in this multicenter sex- and age-matched case-control study.
methodsFive hundred forty-six patients aged 18 to 49 years (median age, 41 [34-46] years; 47.3% women) with a recent CIS and 546 stroke-free community-based controls were included in the study across 19 European centers between October 2013 and November 2022. Mechanical VTRFs, including surgical treatment, nonsurgical intervention, injury, and immobilization occurring within 90 days prestroke, were assessed using standardized, structured interviews. Conditional logistic regression was used to assess the association of mechanical VTRFs with CIS. Age, sex, level of education, and traditional and nontraditional stroke RFs were included as confounders.
resultsMechanical VTRFs within 14 days prestroke were more prevalent in cases than controls (15.4% versus 9.6%) and independently associated with CIS after adjustment for demographics and traditional stroke RFs (odds ratio [OR], 1.67 [95% CI, 1.05-2.67]). In age-stratified analysis, this association remained significant after additional adjustment for nontraditional RFs in 18- to 39-year-olds (OR, 2.36 [95% CI, 1.02-5.46]) but was not significant in the 40- to 49-year age group (OR, 1.50 [95% CI, 0.73-3.08]). In addition, mechanical VTRFs were associated with CIS in cases with clinically relevant patent foramen ovale in a fully adjusted model (OR, 2.06 [95% CI, 1.21-3.51]) but not in those without (OR, 1.29 [95% CI, 0.76-2.18]). No significant associations were observed for mechanical VTRFs occurring >14 days before stroke. Baseline blood thrombophilia markers did not differ between cases with and without mechanical VTRFs 0 to 14 or 15 to 90 days before stroke.
conclusionsRecent mechanical VTRFs occurring within 14 days preceding stroke contribute to the risk of young-onset CIS, particularly in younger individuals and those with a clinically relevant patent foramen ovale. This risk does not appear to be conveyed by thrombophilic factors assessed. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01934725.
Indexed as
Ischemic StrokeVenous ThrombosisAdolescentAdultAge of OnsetBrain IschemiaCase-Control StudiesFemaleHumansMaleMiddle AgedRisk FactorsYoung Adultcase-control studiesembolismforamen ovaleischemic strokepatentrisk factorsthrombophilia
Identifiers
PMID42644242
PMCPMC13619135
What OpenQuestion holds
Textmetadata
Read underepoch 390