Evidence map›Paper›PMID 42644200›Full record

ArticleFrontiers in genetics2026

Benchmarking of Oxford Nanopore whole genome sequencing for germline variant and CpG methylation detection across Canada's national platform for genome sequencing and analysis.

Jose Hector Galvez, Scott Mastromatteo, Kieran O'Neill, Robert Eveleigh, Haig Djambazian, Bhooma Thiruvahindrapuram, Eric Chuah, Shu-Huang Chen, Amirhossein Hajianpour, Zhuozhi Wang and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Jose Hector GalvezMcGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, Canada.
Scott MastromatteoThe Centre for Applied Genomics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Kieran O'NeillCanada's Michael Smith Genome Sciences Centre, BC Provincial Health Services Authority, Vancouver, BC, Canada.
Robert EveleighMcGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, Canada.
Haig DjambazianMcGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, Canada.
Bhooma ThiruvahindrapuramThe Centre for Applied Genomics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Eric ChuahCanada's Michael Smith Genome Sciences Centre, BC Provincial Health Services Authority, Vancouver, BC, Canada.
Shu-Huang ChenMcGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, Canada.
Amirhossein HajianpourThe Centre for Applied Genomics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Zhuozhi WangThe Centre for Applied Genomics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Tara A PatonThe Centre for Applied Genomics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Sachin DesaiThe Centre for Applied Genomics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Sanjeev PullenayegumThe Centre for Applied Genomics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Lan HeThe Centre for Applied Genomics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Pawan PandohCanada's Michael Smith Genome Sciences Centre, BC Provincial Health Services Authority, Vancouver, BC, Canada.
Yongjun ZhaoCanada's Michael Smith Genome Sciences Centre, BC Provincial Health Services Authority, Vancouver, BC, Canada.
Karen MungallCanada's Michael Smith Genome Sciences Centre, BC Provincial Health Services Authority, Vancouver, BC, Canada.
Andrew J MungallCanada's Michael Smith Genome Sciences Centre, BC Provincial Health Services Authority, Vancouver, BC, Canada.
Richard F WintleThe Centre for Applied Genomics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Guillaume BourqueMcGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, Canada.
Stephen W SchererThe Centre for Applied Genomics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Steven JonesCanada's Michael Smith Genome Sciences Centre, BC Provincial Health Services Authority, Vancouver, BC, Canada.
Mark LathropMcGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, Canada.
Meredith McLarenThe Centre for Applied Genomics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Jiannis RagoussisMcGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in sequencing technology have enabled population-level Whole Genome Sequencing (WGS) efforts to be undertaken in many countries. Often, this requires collaboration across a distributed network of sequencing centres to allow efficient use of existing resources. Previously we tested the robustness of short-read sequencing technology and analysis pipelines across three established sequencing centres located in Montreal, Toronto, and Vancouver, constituting CGEn, Canada's national platform for genome sequencing and analysis (www.cgen.ca). In this work, we extend the study to cover

Indexed as

benchmarkinglong-reads sequencingmethylationnanoporewhole genome sequencing

Identifiers

PMID42644200
PMCPMC13506141

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.