ArticleLaryngoscope investigative otolaryngology2026
Beyond the Nerves: Thyroid Autoimmunity as a Non-Neural Factor for Post-Thyroidectomy Dysphonia.
Article in Laryngoscope investigative otolaryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This study aims to investigate the impact of elevated preoperative thyroid autoantibodies, a proposed non-neural contributor, on postoperative voice outcomes, specifically within a cohort of patients undergoing nerve-preserved thyroidectomy verified by intraoperative neuromonitoring (IONM). Methods: A retrospective analysis included 212 patients who underwent primary nerve-preserved thyroidectomy with IONM-confirmed integrity of recurrent and superior laryngeal nerves. Patients were categorized into elevated antibody (EA) and normal antibody (NA) groups according to thyroglobulin antibody (TgAb) and anti-thyroid microsomal antibody (TMAb) levels. Objective and subjective voice analyzes (VHI, VRQoL, and IVST) were performed pre- and postoperatively. Results: The EA group had a significantly higher proportion of bilateral surgeries, larger tumors, and heavier specimens. Several postoperative voice parameters differed significantly between the two groups, and after adjustment for patient characteristics, EA levels remained independently associated with abnormal shimmer (adjusted OR 2.33, Conclusion: In this retrospective exploratory study, elevated thyroid autoantibodies were associated with poorer objective voice stability and greater subjective voice impairment following IONM-verified nerve-preserved thyroidectomy. With standardized IONM minimizing the influence of major neural injury, these findings highlight a potential non-neural influence of thyroiditis on postoperative dysphonia. Shimmer and IVST are useful indicators for detecting subtle functional changes, supporting thyroid antibody status as a practical serological indicator for individualized perioperative counseling and rehabilitation. Level of Evidence: Level III.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.