Evidence map›Paper›PMID 42644013›Full record

ArticleEnvironment & health (Washington, D.C.)2026

Early Life Exposure to PFOS or F‑53B is Associated with Increased Asthma Susceptibility in Offspring and Alterations in the Pulmonary Barrier, Immune Function, and Gut Microbiota.

Zhenying Lin, Xiaoyi Huang, Sujie Sun, Chunyu Cheng, Zelin Cao, Ze Chen, Meng Ni, Yi Hu, Jiuru Zhao, Qianqian Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhenying LinShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Xiaoyi HuangShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Sujie SunShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Chunyu ChengShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Zelin CaoShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Ze ChenShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Meng NiShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Yi HuShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Jiuru ZhaoShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Qianqian ZhangShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Xiaorui LiuShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Zhiwei LiuShanghai Key Laboratory of Embryo Original Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.ORCID https://orcid.org/0000-0003-4926-1319

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As perfluorooctanesulfonate (PFOS) is phased out, its alternative, 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), has been widely used in China. However, the health risks associated with F-53B exposure, particularly its potential effects on offspring respiratory outcomes, remain largely unclear. We therefore investigated whether gestational and lactational exposures to PFOS or F-53B alter early lung development and influence asthma susceptibility in offspring. Pregnant mice were exposed to PFOS or F-53B at a dose relevant to the human tolerable daily intake of PFOS during gestation and lactation, and maternal-fetal distribution was quantified by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) at embryonic day 18.5. Both PFOS and F-53B efficiently crossed the placenta and accumulated in the fetal lungs. Following ovalbumin sensitization and challenge, offspring from exposed dams showed increased airway inflammatory pathology and goblet cell hyperplasia, along with higher bronchoalveolar lavage protein and elevated pulmonary

Indexed as

6:2 chlorinated polyfluoroalkyl ether sulfonateasthmamaternal exposureperfluorooctanesulfonates

Identifiers

PMID42644013
PMCPMC13504555

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.