ArticleEnvironment & health (Washington, D.C.)2026
Cotinine Promotes Cancer Cell Proliferation and m
Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicotine is the most abundant alkaloid in tobacco, and 70%-80% of its metabolites are cotinine. In terms of that, numerous cigarettes are consumed worldwide, resulting in a large amount of cotinine being released into the environment and posing potential hazards. However, the biological effects of cotinine are poorly understood. In the current study, we identified that the oncogene Polo-like kinase 1 (PLK1) is a direct target of cotinine, and cotinine could upregulate the protein level of PLK1. Public epidemiological data indicated a positive correlation between PLK1 expression and smoking. Subsequent studies validated that PLK1 directly interacted with β-catenin, leading to transcriptional activation of tRNA methyltransferase 6 (TRMT6), a canonical methyltransferase involved in m
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.