Evidence map›Paper›PMID 42643739›Full record

ReviewFrontiers in immunology2026

Therapeutic biologics interference in serological and pre-transfusion testing.

Philipp Trummer, Cora P Habicht, Erwin A Scharberg, Clemens Schneeweiß

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Philipp Trummerimusyn GmbH & Co. KG, Hannover, Germany.
Cora P Habichtimusyn GmbH & Co. KG, Hannover, Germany.
Erwin A ScharbergSYNLAB MVZ Leinfelden GmbH, Leinfelden-Echterdingen, Germany.
Clemens Schneeweißimusyn GmbH & Co. KG, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of therapeutic antibodies has revolutionized the treatment landscape for various diseases, particularly in oncology and immunology. These highly specific biologic agents bind cell surface proteins, offering targeted therapeutic strategies with potentially fewer side effects compared to traditional treatments. However, the increasing use of these antibodies has introduced new challenges in transfusion and transplantation diagnostics. This review article explores how therapeutic biologics interfere with serological and pre-transfusion testing, focusing on biologics that target CD20, CD38, and CD47, discusses current remedies and solutions to mitigate these interferences, and considers possible interferences from new drugs and drug targets.

Indexed as

Biological ProductsBlood Grouping and CrossmatchingBlood TransfusionAnimalsAntibodies, MonoclonalAntigens, CD20CD47 AntigenHumansSerologic TestsAntibodies, MonoclonalAntigens, CD20Biological ProductsCD47 Antigenanti-CD20 antibodiesanti-CD38 antibodiesanti-CD47 antibodieshistocompatibility testingpre-transfusion testingtherapeutic antibody interferencetherapeutic biologics interference

Identifiers

PMID42643739
PMCPMC13504806

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.