ArticleFrontiers in molecular biosciences2026
Exploring the toxicity of extracts, fractions, and their bioactive components from raw and roasted sea buckthorn seeds on selected human cells.
Article in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: With cancer being one of the leading causes of death worldwide, research into new chemical compounds that could be used in its prevention and treatment is of utmost importance. Plants are rich in diverse active compounds and can be a source of effective anticancer agents. Sea buckthorn ( Methods: Our present study assessed the Results and discussion: Fraction b (containing mostly flavonol glycosides) had the most promising anticancer activity out of all the tested samples - at the concentration of 50 μg/mL, it decreased the viability of HL-60 cells through the induction of apoptosis. At the same time, it was safe for PBMC and blood platelets. On the other hand, fraction c (that contained serotonin, B-type proanthocyanidins, and other compounds) stimulated A549 cells and, therefore, should be treated with caution. Fractions from roasted seeds were overall weaker than fractions from raw seeds, suggesting that thermal processing might have reduced their activity. In conclusion, fraction b from raw sea buckthorn seeds showed anticancer potential against HL-60 cells, but it should be studied further to determine the activity of individual compounds contained within, their mechanisms of action, and efficiency
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